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Inverse opal structure microneedle array with structural color and preparation method and application thereof

A technology of anti-opal structure and microneedle array, which is applied in the field of microneedle array, anti-opal structure microneedle array and its preparation, can solve the problems of inability to monitor the drug release process and limited uploading, and achieve low price, convenient operation, The effect of easy operation

Active Publication Date: 2022-07-22
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the shortcomings of traditional microneedles, such as the limitation of drug loading and the inability to monitor the drug release process, the present invention uses the opal structure of photonic crystals as a template to provide a microneedle with a structure Colored anti-opal structure microneedle array and its preparation method and application in the preparation of transdermal drug delivery

Method used

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  • Inverse opal structure microneedle array with structural color and preparation method and application thereof
  • Inverse opal structure microneedle array with structural color and preparation method and application thereof
  • Inverse opal structure microneedle array with structural color and preparation method and application thereof

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Embodiment 1

[0027] This embodiment provides an inverse opal structure microneedle array with structural color using silica nanoparticles with a particle size of 150 nm as a template. Its preparation method comprises the following steps:

[0028] Step 1: Prepare silica nanoparticles with a particle size of 150 nm into an alcohol solution of silica nanoparticles with a concentration of 3w / v%, and ultrasonically mix them for 1 hour. The PDMS microneedle template was treated with a plasma cleaner for 5 min. The mixed silica nanoparticle alcohol solution was injected into the PDMS microneedle template, vacuumed for 5 min, and the air was evacuated. Afterwards, the deposition method was used at 25°C for 4 hours. After the solvent was evaporated, it was moved gently. At this time, a self-assembled silica colloidal crystal, ie, a photonic crystal microneedle template, was obtained in the PDMS microneedle template.

[0029] Step 2. Use 80w / v% PEGDA and 1v / v% HMPP (photoinitiator) to prepare a hy...

Embodiment 2

[0034] This embodiment provides an inverse opal structure microneedle array with structural color using silica nanoparticles with a particle size of 200 nm as a template. Its preparation method comprises the following steps:

[0035] Step 1: The silica nanoparticles with a particle size of 200 nm are prepared into an alcohol solution of silica nanoparticles with a concentration of 3w / v%, and are ultrasonically mixed for 1 hour. The PDMS microneedle template was treated with a plasma cleaner for 5 min. The mixed silica nanoparticle alcohol solution was injected into the PDMS microneedle template, vacuumed for 5 min, and the air was evacuated. Afterwards, the deposition method was used at 25°C for 4 hours. After the solvent was evaporated, it was moved gently. At this time, a self-assembled silica colloidal crystal, ie, a photonic crystal microneedle template, was obtained in the PDMS microneedle template.

[0036] Step 2. Use 80w / v% PEGDA and 1v / v% HMPP (photoinitiator) to pr...

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Abstract

The invention discloses an inverse opal structure microneedle array with structural color and a preparation method and application thereof, and the preparation method comprises the following steps: step 1, preparing colloidal particles into a colloidal particle solution, injecting the colloidal particle solution into a microneedle mold, and depositing to obtain a photonic crystal microneedle template; and 2, preparing a hydrogel polymerization precursor solution, pouring the hydrogel polymerization precursor solution into the microneedle mold with the photonic crystal microneedle template to polymerize and cure the hydrogel polymerization precursor solution, then enabling the cured microneedle to fall off from the mold, and removing the photonic crystal microneedle template to obtain the inverse opal structure microneedle array with the structural color. The device has the advantages of reusability, low cost, simplicity in operation, convenience, reliability and the like.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a microneedle array, in particular to an inverse opal structure microneedle array with structural color and a preparation method and application thereof. Background technique [0002] Transdermal drug delivery is a method of drug absorption, which aims to promote the absorption of drugs through the skin into the human blood circulation and achieve effective blood drug concentrations. Compared with oral drug delivery and subcutaneous injection, transdermal drug delivery has advantages in reducing injection pain, avoiding first-pass effect, stable and controllable blood drug concentration, and patient compliance. In recent years, various transdermal drug carriers have been developed to improve drug delivery efficiency. Among them, the microneedle array is one of the effective transdermal drug carriers, which can penetrate the skin to form microporous channels and promote the pene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/04A61K47/32A61K47/34A61K47/42A61M37/00
CPCA61K9/0021A61K47/02A61K47/34A61K47/42A61K47/32A61M37/0015A61M2037/0046A61M2037/0053A61M2037/0061
Inventor 赵远锦卢敏慧张大淦商逸璇
Owner NANJING DRUM TOWER HOSPITAL
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