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Method for identifying spotted tumor cattle variety by using KIT gene copy number variation genetic marker

A technology of gene copy number and genetic marker, applied in the field of molecular markers, can solve the problems of complex situation, high analysis difficulty, undetermined main effect gene, etc., to achieve the effect of improving efficiency

Pending Publication Date: 2022-07-08
NORTHWEST A & F UNIV +1
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Problems solved by technology

[0006] At present, there is no research on CNV related to zebu's spotted coat color. In particular, the main gene that affects the spotted coat color of zebu has not been determined so far. Different, there are many different combinations, and the specific coat color traits may be affected by more than one gene and various gene variations, the situation is complicated and the analysis is difficult

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  • Method for identifying spotted tumor cattle variety by using KIT gene copy number variation genetic marker
  • Method for identifying spotted tumor cattle variety by using KIT gene copy number variation genetic marker
  • Method for identifying spotted tumor cattle variety by using KIT gene copy number variation genetic marker

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Embodiment Construction

[0031] The present invention will be described in further detail below with reference to the accompanying drawings and embodiments. The embodiments are only used to explain the present invention, but not to limit the protection scope of the present invention.

[0032] (1) Using genome-wide resequencing, genome-wide association analysis, and genome-wide selective scavenging to explore candidate genetic markers for the coat color gene of Zebra zebu

[0033] (1.1) Collected 19 zebu ear tissue samples from Pakistan (9 Cholistani, 10 Dhanni, ear tissue samples were collected in November 2020, collected by Quratulain Hanif, a member of the team), and 22 pure white Burmese were collected from Myanmar Bovine ear tissue samples (collected in December 2019) were compared with genomic DNA data of 30 solid-colored zebu cattle (ear tissue samples were also collected in Pakistan) and 22 solid-colored Burmese cattle.

[0034] Coat color traits of 19 zebu cattle collected: Cholistani's spots...

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Abstract

The invention discloses a method for identifying a spotted tumor cattle variety by using a KIT gene copy number variation genetic marker. The variety identification of spotted tumor cattle is realized according to a CNV section which contains about 490Kb of a KIT gene and is subjected to repeated mutation on a cattle chromosome 6 found by carrying out whole genome CNV analysis on spotted hair color character tumor cattle and other pure color hair color character cattle varieties. According to the CNV segment, molecular marker-assisted selection can be carried out on tumor cattle hair color characters on the DNA level, so that a population with excellent genetic resources is rapidly established.

Description

technical field [0001] The present invention relates to molecular markers in the introduction and breeding of zebu (Bos indicus), in particular to the detection of copy number variation genetic markers (CNV markers) closely related to Zebu's spotted coat color at the DNA level, and the use of CNV markers to distinguish spot tumors Cattle (ie spotted zebu) and other cattle breeds (eg solid zebu). Background technique [0002] Copy number variation (CNV) is a copy number variation involving DNA fragments of 1 Kb or larger. The copy number of fragments compared to the reference genome may vary between breeds, and this difference is heritable. Copy number variation affects the duplication or deletion of a considerable number of base pairs in the chromosomes of eukaryotes, which is manifested as the continuous repetition or loss of a certain segment on the chromosome. The site of copy number variation is not limited to functional genes. Also present in nonsense intergenic regio...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12Q1/6869G16B20/10G16B20/20
CPCC12Q1/6888C12Q1/6869G16B20/10G16B20/20C12Q2600/158C12Q2600/156
Inventor 陈宁博雷初朝王文祥马志杰夏小婷库尔图兰·哈尼夫沙希德·曼苏尔
Owner NORTHWEST A & F UNIV
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