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Preparation method of hair follicle stem cell tissue paste for treating depressed scars

A hair follicle stem cell and tissue technology, applied in the direction of non-embryonic pluripotent stem cells, animal cells, vertebrate cells, etc., can solve the problems of poor epidermal repair, unsatisfactory effect, and long recovery time, and achieve strong self-renewal ability and in vitro The effect of strong proliferative ability and increased growth speed

Pending Publication Date: 2022-07-08
HAIKOU RENSHU DERMATOLOGY CLINIC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages: high technical requirements for cell culture, high cost, poor effect on epidermal repair
This invention perfectly solves the problems of large damage, long recovery time, unsatisfactory effect, easy recurrence, and large side effects in scar treatment in the above-mentioned background technology.

Method used

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  • Preparation method of hair follicle stem cell tissue paste for treating depressed scars

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Experimental program
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Effect test

Embodiment 1

[0048] Step S1, the extraction of hair follicle, adopts FUE technology to extract a hair follicle unit;

[0049] In step S2, the hair follicle unit is separated and extracted. Under the state of magnification of 2-10 times, the hair follicle stem cells and the skin regeneration tissue around the hair follicle are separated under an electron microscope or a magnifying glass, and the epidermis and the hair shaft above the epidermis basal layer from which the hair follicle unit is obtained are removed, and retained. The tissue around the hair follicle and the extracted intact hair bulb, skin appendages such as sebaceous glands and sweat glands, and associated subcutaneous fat. Provide material guarantee for the preparation of active hair follicle stem cell regeneration tissue mud. Step S3, in vitro culture, put the hair follicle stem cells and the skin regeneration tissue around the hair follicle separated in step S2 into a special culture solution for activation, culture at 24-2...

Embodiment 2

[0056] In this embodiment, the effective rate of treating depressed scars with hair follicle stem cell regeneration tissue mud reaches more than 100%. The clinical comparison of the present invention shows that the repair time of hair follicle stem cell regeneration tissue mud for depressed scars is significantly shorter than other treatments, and the curative effect is significantly improved. .

[0057] The technical difficulty of the present invention: "the integrity of hair follicle stem cells and skin appendages" refers to whether the hair follicle stem cells can survive directly after implantation, which is related to the later treatment effect. The autologous hair follicle stem cells that have been specially isolated and cultured in vitro have the characteristics of slow periodicity, strong self-renewal ability, high proliferation ability, and multi-differentiation potential, and can continue to repair scar tissue after transplantation.

[0058] Principle of the present ...

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Abstract

The invention discloses a method for preparing and using hair follicle stem cell regeneration tissue mud in the process of treating concave scars through hair follicle stem cell and hair follicle surrounding skin regeneration tissue transplantation. The method comprises the following steps: 1, extracting a complete hair follicle unit; 2, separating hair follicle stem cells and skin regeneration tissues around hair follicles; 3, in-vitro culture and activation of hair follicle stem cells; 4, preparation of hair follicle stem cell regeneration tissue mud; and 5, filling concave scars. The method comprises the following steps: extracting hair follicle units to obtain skin regeneration tissues around hair follicle stem cells, culturing by using a special in-vitro culture solution, and further activating the hair follicle stem cells by using an anti-sensitivity instrument, so as to prepare tissue cell mud which can be used for filling; the purposes of filling and leveling concave scars, inhibiting scar hyperplasia, softening and smoothing the scars and repairing and beautifying the concave scars are achieved.

Description

technical field [0001] The invention relates to the technical field of treatment of scars in skin diseases, in particular to a preparation method of hair follicle stem cell tissue mud in the process of treating scars with hair follicle stem cells and surrounding active tissues. Background technique [0002] Depressed scars are scars caused by defects in the dermis and subcutaneous tissue of the skin. Acne, surgery, trauma, infection, chickenpox, and smallpox are common causes of depressed scars. These causes lead to defects in the dermis and subcutaneous tissue of the skin, and the loss of collagen and elastin in the subsequent healing process will leave permanent scars. Depressed scars. [0003] Harmfulness of sunken scars: Scar is an inevitable product in the process of human trauma repair. In a broad sense, there is no wound healing without scars. The main component of scar tissue is fibrin. The production and deposition of collagen in scar tissue increases wound stren...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61P17/02C12N5/074C12N5/071
CPCA61K35/36A61P17/02C12N5/0628C12N5/0625C12N2501/30C12N2500/32C12N2501/999C12N2500/84
Inventor 刘景卫
Owner HAIKOU RENSHU DERMATOLOGY CLINIC CO LTD
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