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Composition for treating alcoholic stomach injury and gastric ulcer as well as preparation method and application of composition

A gastric ulcer and alcoholic technology, applied in the field of biomedicine preparation, can solve problems such as sexual dysfunction, and achieve significant and good drug effects

Pending Publication Date: 2022-06-24
上海朗泰凯尔生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main therapeutic drugs are chemical drugs and traditional Chinese medicine. Chemical drugs are mainly combined with H2 proton pump inhibitors and M1 receptor blockers. However, long-term use of chemical drugs may cause adverse reactions such as arrhythmia and sexual dysfunction.

Method used

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  • Composition for treating alcoholic stomach injury and gastric ulcer as well as preparation method and application of composition
  • Composition for treating alcoholic stomach injury and gastric ulcer as well as preparation method and application of composition
  • Composition for treating alcoholic stomach injury and gastric ulcer as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The present invention includes bovine liver active peptide and active polysaccharide, the bovine liver active peptide is His-Tyr-Gly-His oligopeptide, and the structure of the bovine liver active peptide is

[0024]

[0025] Active polysaccharides include yam active polysaccharide, licorice active polysaccharide, Agaricus blazei active polysaccharide, Poria cocos active polysaccharide and Ganoderma lucidum active polysaccharide. The mass ratio of bovine liver active peptide to yam active polysaccharide, licorice active polysaccharide, Agaricus blazei active polysaccharide, Poria cocos active polysaccharide and Ganoderma lucidum active polysaccharide was 0.01:3:3:5:3:3.

[0026] The present invention is suitable for gastric ulcer and gastric injury caused by ethanol, and the composition of the present invention can be prepared into food, health product, functional food or medicine for treating alcoholic gastric injury and gastric ulcer by adding auxiliary materials.

...

Embodiment 2

[0067] The difference between this example and Example 1 is that the active polysaccharides include yam active polysaccharide, Agaricus blazei active polysaccharide and Poria cocos active polysaccharide. The yam active polysaccharide, Agaricus blazei active polysaccharide and Poria cocos active polysaccharide with molecular weights of 3-5 kD were prepared by dialysis bag dialysis. The mass ratio of bovine liver active peptide to yam active polysaccharide, Agaricus blazei active polysaccharide and Poria cocos active polysaccharide was 0.01:10:10:10.

Embodiment 3

[0069] The difference between this example and Example 1 is that the active polysaccharides include yam active polysaccharides and Ganoderma lucidum active polysaccharides. The yam polysaccharides and Ganoderma lucidum polysaccharides are dissolved in 10 times of purified water, and the dissolving solution is a dialysis bag with a pore size of 10 kD. The yam active polysaccharide and the Ganoderma lucidum active polysaccharide with a molecular weight of 5-10 kD were obtained by dialysis. The mass ratio of bovine liver active peptide to yam active polysaccharide and Ganoderma lucidum active polysaccharide was 0.01:5:10.

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Abstract

The invention belongs to the technical field of biological medicine preparation, and particularly relates to a composition for treating alcoholic stomach injury and gastric ulcer and a preparation method and application thereof. The bovine liver active peptide composition comprises one or more of bovine liver active peptide and a plurality of active polysaccharides, the mass percentage of the bovine liver active peptide to the active polysaccharides is 0.01: (5-50), and the bovine liver active peptide is Hi-Tyr-Gl y-Hi s oligopeptide. The optimal active ingredients of the Chinese yam polysaccharide, the glycyrrhiza polysaccharide, the agaricus blazei polysaccharide, the pachymaran, the ganoderma lucidum polysaccharide and the bovine liver active peptide are extracted through a simple activity tracking method, and then the optimal active ingredients are combined to obtain the composition. The composition has a very remarkable pharmacodynamic effect when being used for treating alcoholic stomach injury and gastric ulcer, and particularly has a better pharmacodynamic effect on stomach injury and gastric ulcer caused by ethanol.

Description

technical field [0001] The invention belongs to the technical field of biological medicine preparation, and particularly relates to a composition for treating alcoholic gastric injury and gastric ulcer, and a preparation method and application thereof. Background technique [0002] Gastric ulcer is a kind of peptic ulcer that occurs in the antrum, gastric angle and cardia. Common causes are Helicobacter pylori infection, drugs and diet, stress and other factors. Its clinical characteristics are long-term recurring, rhythmic epigastric pain, which usually occurs 1 hour after eating. Due to the huge pressure of people's life and work, drinking has become a habit in people's lives. A large number of studies have shown that long-term heavy drinking can cause acute or chronic damage to the gastric mucosa, and the main pathological manifestations are gastric mucosal congestion, erosion and ulcers. At present, the main treatment drugs are chemical drugs and traditional Chinese m...

Claims

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Application Information

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IPC IPC(8): A61K38/07A61P1/04A23L33/18A23L33/125C07K5/117C07K1/14A61K31/715
CPCA61K38/07A61K31/715A61P1/04A23L33/18A23L33/125C07K5/1024A61K35/407A23V2002/00A61K2300/00A23V2200/32A23V2250/50
Inventor 刘杰王尔一王怀玲马龙鹏郑曼王文雅刘晓蕾
Owner 上海朗泰凯尔生物技术有限公司
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