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A composition, cannabinoid technology, applied in the directions of drug delivery, active ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc.
Pending Publication Date: 2022-06-10
BLACKHAWK PARTNERS LTD
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[0010] However, while intact plant cells are useful in a variety of situations, in some cases forming pharmaceutical compositions from intact plant cells may not be preferred
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[0050] Solvent extraction of cannabinoids from cannabis plants and isolation of specific cannabinoids is well known in the art. One such method is disclosed in US 6,403,126, and the method disclosed in this patent is applicable to the present invention. In particular, the method of US 6,403,126 is suitable for the extraction of cannabinoids from cannabis sativa.
[0051] In this method, cannabis powder is extracted with a solvent such as ethanol for a period of two to four hours. The solvent can then be evaporated to leave a residue. The extracted residue may then be passed through a chromatography column arranged to fractionate the at least one cannabinoid. The fractionated cannabinoid(s) can then be used to form pharmaceutical compositions.
[0052] ii) Extraction of glutathione
[0053] Material: 10g dried cannabis leaves
[0054] 100ml deionized water
[0055] 250ml erhlingmeyer flask
[0056] Magnetic Stirrers and Rods
[0057] Filter paper
[0058] filter funnel...
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Abstract
The present invention provides a pharmaceutical composition consisting of: a first pharmaceutically active part consisting of one or more cannabinoids; a second pharmaceutically active part consisting of one or more of glutathione, cysteine, acetylcysteine, alliin, briximine, carboxy methylcysteine, mucine, cat urine, lantidine, mesine hydrochloride, penicillamine cysteine disulfide, or any functional equivalent thereof; and a pharmaceutical composition comprising the first pharmaceutically active part and the second pharmaceutically active part, wherein the second pharmaceutically active part consists of one or more of glutathione, cysteine, acetylcysteine, alliin, briximine, carboxy methylcysteine, mucine, cat urine, lantidine, mesine hydrochloride, penicillamine cysteine disulfide or any functional equivalent thereof. And optionally one or more excipients; wherein the molar ratio of the second pharmaceutically active moiety to the first pharmaceutically active moiety is at least 0.5: 1, advantageously at least 1: 1. The composition of the present invention is advantageous in that it can prevent hepatotoxicity that may be caused by ingestion of isolated cannabinoids. The present invention also provides a method of manufacturing a pharmaceutical composition comprising the steps of: extracting a first fraction comprising one or more cannabinoids from cannabis plant material using a polar solvent; extracting a second fraction comprising glutathione from the same cannabis plant material using water; and drying and combining the first fraction and the second fraction to form the pharmaceutical composition.
Description
field of invention [0001] The present invention relates to the medicinal use of cannabinoids extracted from cannabis plants and cells of cannabis plants. [0002] background [0003] Historically, cannabis sativa (cannabis) is an illicit drug that has been consumed for recreational purposes. This is largely due to the psychoactive compound tetrahydrocannabinol (THC), a cannabinoid present in marijuana. However, cannabis also contains a number of other cannabinoids including, but not limited to, cannabidiol and cannabinol. [0004] Cannabis has been smoked, but it has also been ingested in plant or resinous form. More recently, cannabis has been used for therapeutic reasons to treat a variety of ailments, with varying degrees of success. Due to the illicit nature of cannabis, even therapeutic use of the drug generally still involves smoking or ingesting the whole plant or resin, and there has been little research into the efficacy of this therapeutic use. Additionally, be...
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