Mutual transformation method of functional components of radix sophorae flavescentis
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A technology of mutual conversion and functional components, applied in the field of biomedicine, can solve the problem of low purity of matrine
Active Publication Date: 2022-06-07
西安岳达生物科技股份有限公司
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[0007] The purpose of the present invention is to provide a method for mutual conversion of functional component
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Embodiment 1
[0028] Embodiment 1 A kind of transformation method of Sophora flavescens functional component
[0029] Include the following steps:
[0030] (1) Take 1Kg of matrine root pieces, boil and extract three times with 5kg of pure water each time, combine the filtrates, concentrate to 500ml under reduced pressure, use 2000ml of methanol for alcohol precipitation, the ratio is 4:1, filter, discard the filter cake , spin off the methanol from the filtrate, adjust the pH of the filtrate to 2 with 10% hydrochloric acid solution, and extract three times with ethyl acetate. The aqueous phase was adjusted to pH 11 with an aqueous sodium hydroxide solution, extracted three times with chloroform, the amount of chloroform each time was three times the volume of the original water phase, the chloroform phases were combined, and the chloroform phase was spin-dried under reduced pressure at a low temperature. , get 25g of matrine and matrine mixture.
[0031] (2) Dissolve 5.0 g of the mixture ...
Embodiment 2
[0033] Embodiment 2 A kind of transformation method of Sophora flavescens functional component
[0034] Include the following steps:
[0035] (1) Take 1Kg of matrine root pieces, boil and extract three times with 5kg of pure water each time, combine the filtrates, concentrate to 500ml under reduced pressure, use 1500ml of methanol for alcohol precipitation, the ratio is 3:1, filter, discard the filter cake , spin off the methanol from the filtrate, adjust the pH of the filtrate to 2 with 10% hydrochloric acid solution, and extract three times with ethyl acetate. The aqueous phase was adjusted to pH 11 with an aqueous sodium hydroxide solution, extracted three times with chloroform, the amount of chloroform each time was three times the volume of the original water phase, the chloroform phases were combined, and the chloroform phase was spin-dried under reduced pressure at a low temperature. , to get 24.6g of the mixture of matrine and matrine.
[0036] (2) Dissolve 5.0 g of ...
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Abstract
The invention discloses a mutual transformation method of functional components of radix sophorae flavescentis. The functional components comprise matrine and kushenin. The method comprises the following steps: by taking radix sophorae flavescentis as a raw material, extracting with pure water, carrying out alcohol precipitation, and extracting to obtain a mixture of matrine and kushenin; the obtained matrine and kushenin mixture is oxidized with an oxidizing agent, so that matrine is oxidized into kushenin, then neutral aluminum oxide is used for chromatography, and high-purity kushenin is obtained; and/or reducing the kushenin into the matrine by using a reducing agent in the obtained matrine and kushenin mixture, and then performing chromatography by using neutral aluminum oxide to obtain the high-purity matrine. By using the method disclosed by the invention, the mutual transformation of the matrine and the kushenin can be completed according to actual requirements, and the matrine and the kushenin with high purity can be prepared. The invention provides an effective technical means for extraction and preparation of functional components of sophora flavescens.
Description
technical field [0001] The invention relates to a method for mutual transformation of functional components of Sophora flavescens, belonging to the technical field of biomedicine. Background technique [0002] Matrine and matrine are alkaloids extracted from the dried roots, plants and fruits of the leguminous plant Sophora flavescens by ethanol and other organic solvents. It is generally total alkaloids of matrine, and its main components are matrine, matrine, sophocarpine, oxysophocarpine, sophoridine and other alkaloids, with matrine and oxymatrine having the highest content. The other sources are the root of rhizoma rhizome and the aerial part of root of rhizoma rhizome, and the pure product is white powder. [0003] As a medicinal plant, Sophora flavescens has a history of more than 2,000 years in my country according to written records. . When matrine was injected into rabbits, it was found that the central nervous system was paralyzed, with convulsions, and finally ...
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