Application of reagent for inhibiting pyroptosis of platelets in preparation of medicine for preventing and/or treating sepsis

Abstract

The invention discloses application of a reagent for inhibiting pyroptosis of platelets in preparation of a medicine for preventing and / or treating sepsis, and the sepsis is severe sepsis or septic shock. In the invention, the inventor finds out the close relevance between severe sepsis and pyroptosis of platelets for the first time, reveals the pathological process of GSDMD-dependent pyroptosis of platelets, and finds that pyroptosis of platelets is generated based on induction of abnormally increased S100A8 / A9 in plasma through up-regulation of a TLR4 signal channel. Therefore, a theoretical basis is provided for development of targeted treatment targets of severe sepsis. Moreover, specific GSDMD knockout platelets and TLR4 knockout platelets are successfully constructed, the treatment effect of the specific GSDMD knockout platelets and the specific TLR4 knockout platelets on severe sepsis is proved through platelet replacement or infusion and other modes, and a new treatment strategy is provided for excessive inflammatory response of severe sepsis and platelet infusion.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the use of an agent for inhibiting platelet pyroptosis in the preparation of a medicament for preventing and / or treating sepsis. Background technique [0002] Sepsis is a systemic inflammatory response syndrome caused by infection, which is one of the main causes of death of children worldwide. The prevention and early treatment of sepsis is extremely important for the patient's family. [0003] Relevant technical studies have shown that the global fatality rate of sepsis hospitalization is about 12.1%, of which the fatality rate of septic shock reaches 32.3%. Although in recent years, the global medical level and the public's living standards have been continuously improved, especially the attention to the health and disease treatment of infants and young children is also increasing, but in actual clinical practice, sepsis with a high fatality rate in children's intensive ...

AI Technical Summary

Problems solved by technology

At present, antibiotics and symptomatic and supportive treatment are mostly used in the clinical treatment of sepsis, but the effect is limited and the course of the disease is likely to aggravate, which will not only bring a serious economic burden to the patient's family, but also bring great psychological panic to the patient's family. Not conducive to further treatment of the disease

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