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Arrangement for improved gas exchange through semi-permeable membranes in aqueous environments

A gas and gas carrier technology, used in dialysis systems, drug devices, blood circulation treatment, etc., to achieve the effect of less induced coagulation

Pending Publication Date: 2022-05-27
普美迪泰克德国有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] CO removal in parallel with dialysis 2 During dialysis, it is also problematic that sodium bicarbonate is frequently used as a dialysate buffer during dialysis in order to balance the metabolic acidosis of renal failure

Method used

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  • Arrangement for improved gas exchange through semi-permeable membranes in aqueous environments
  • Arrangement for improved gas exchange through semi-permeable membranes in aqueous environments
  • Arrangement for improved gas exchange through semi-permeable membranes in aqueous environments

Examples

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Embodiment approach 1

[0052] In a first embodiment, CO is enriched 2 of blood is pumped at 200ml / min through a dialyzer (which ideally has an asymmetric membrane such as a Fresenius FX1000 Cordiax TM A hollow fiber of polysulfone in and for CO removal 2 oxygenator. exist figure 1 The structure is shown in . First, there is no oxygen inflow to the oxygenator. Although the hemoglobin dialysate solution is continuously circulating, CO 2 clearance decreases over time as dialysate hemoglobin is enriched with CO 2 . After 2.5 minutes, O to the oxygenator 2 The supply was set to 600ml / min. remove CO 2 The effect is shown in figure 2 middle.

[0053] exist figure 1 A blood circuit (hematocrit approx. 40%) is shown in , which is driven by a hose pump 1 and flows through the dialyzer on the inside of the hollow fibers. The dialyzer is a commercially available asymmetric high-flux polysulfone dialyzer (sieving coefficient for albumin 2 Poisoning, downstream of sensor SH2, directly upstream of p...

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Abstract

The invention describes a method and an arrangement in which gases are removed from possibly complex aqueous biological mixtures via a semi-permeable membrane by dialysis in an aqueous environment, in which specialized carrier molecules for the gases are used in the dialysate and these carrier molecules are regenerated in the dialysate circuit, therefore, the membrane can be used for further gas exchange circulation on the membrane.

Description

technical field [0001] The present invention relates to a method and an arrangement for improving gas exchange through a semi-permeable membrane in an aqueous environment. Background technique [0002] The introduction of oxygen or the removal of carbon dioxide from complex and / or biological fluids is used, for example, in the treatment of blood. [0003] In this case, the prior art is based on so-called oxygenators, which consist of semi-permeable membranes made of hydrophobic, porous materials. Typically, the pores of the oxygenator are impermeable to blood cells. In this case, the blood is guided along one side and the gas, eg air, oxygen or other gas mixture, is guided on the other side. The gas exchange first takes place at the interface between the serum and the gas phase, where the gas is first physically dissolved in the serum and exchanged with the red blood cells. [0004] The hydrophobicity of the material prevents the serum from passing through the blood side ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16A61M1/32A61M1/36
CPCA61M1/32A61M1/3666A61M1/1698A61M1/1676A61M2202/0433A61M2202/0007A61M1/1603A61M1/1621A61M1/1627A61M1/1654A61M2202/0208A61M2202/0225A61M2202/0413
Inventor 让·施坦格让·克莱贝尔
Owner 普美迪泰克德国有限公司
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