Artificial saliva composition containing mucoprotein as well as preparation method and application of artificial saliva composition

Abstract

The invention belongs to the technical field of oral medicine and health care, and particularly relates to an artificial saliva composition containing mucoprotein as well as a preparation method and application of the artificial saliva composition. The artificial saliva composition containing mucoprotein provided by the invention is prepared from mucoprotein, placenta globulin, biological enzyme, inorganic solute, a bacteriostatic agent, xylitol, malic acid, a humectant, sodium hyaluronate and water. The mucoprotein-containing artificial saliva composition provided by the invention has similar components to natural saliva components, has a good taste, can inhibit oral bacterial reproduction, has a good antibacterial property, can enhance human immunity and inhibit pathological changes of oral mucosa, and has a good treatment effect on xerostomia. Besides, the artificial saliva composition containing mucoprotein provided by the invention has certain viscosity, can wrap teeth and gingiva, provides a physical barrier for protecting the teeth, and is adhered to bacteria capable of causing gingival diseases to destroy the ability of the bacteria to injure the teeth.

Description

technical field [0001] The invention belongs to the technical field of oral medicine and health care, and in particular relates to an artificial saliva composition containing mucin and its preparation method and application. Background technique [0002] Radiotherapy to the head and neck can affect the secretory function of the salivary glands, resulting in a decrease in the amount of saliva, that is, xerostomia. Xerostomia is the pain of various diseases with dry mouth as the main symptom. Patients will experience burning sensation in the mouth, difficulty swallowing, ulcers or pain, and loss of taste. Patients with complete dentures in the mouth may also experience poor denture retention. Due to the lack of self-cleaning and anti-adhesion functions of saliva, such patients are also prone to violent caries. The reduction of saliva may cause pathological changes in the oral mucosa of such patients, which seriously affects the lives of patients. [0003] For patients with d...

AI Technical Summary

Problems solved by technology

The reduction of saliva may cause pathological changes in the oral mucosa of such patients, which seriously affects the lives of patients.

[0003] For patients with dry mouth, artificial saliva is often used as a substitute for saliva to relieve their dry mouth symptoms. There are many types of artificial saliva for patients with dry mouth, but it is very difficult to treat dry mouth. Most artificial saliva is based on carboxymethyl cellulose. The main raw material, this product does not stimulate the non-Newtonian properties of saliva, and does not contain special antibacterial components (including antibodies), enzymes and other components in saliva

[0004] The patent publication No. CN103561719A discloses an oral composition, and its formulation components include extracts from Araliaceae, Zingiberaceae, Lamiaceae, Fabaceae, Solanaceae, Pomegranate, Compositae or mixtures thereof. Composition, this oral composition has the effect of reducing dry mouth, but this oral composition can not reduce the pathological changes of the mucosa in the oral cavity

Although this oral care composition has the effects of treating gingivitis, reducing halitosis, and having bactericidal effects, its ingredients are quite different from natural saliva, and its mouthfeel is relatively poor.

[0006] In summary, there are generally technical problems in the prior art such as poor antibacterial properties, inability to inhibit pathological changes of oral mucosa, large differences between ingredients and natural saliva, and poor taste.

Images