Application of kibra rs17070145 detection reagent in the preparation of olfactory function evaluation kit

Abstract

The invention relates to the application of KIBRA rs17070145 detection reagent in the preparation of olfactory function evaluation kit. Olfactory function is an important reference basis for clinical disease diagnosis, and the present invention studies the correlation between the control brain area and genotype of olfactory function. Studies have shown that the gray matter volume (GMV) of the bilateral orbitofrontal area and left thalamus of KIBRA TT carriers is significantly lower than that of C allele carriers, which can be judged as anosmia. The corrected OR of CC and CT genotypes and olfactory disturbance was 0.687, and the older the age, the stronger the protective effect of the C allele on olfactory function, and the lower the possibility of olfactory disturbance. Based on the above achievements, the present invention provides the application of KIBRA rs17070145 detection reagent in the preparation of olfactory function evaluation kit.

Description

technical field [0001] The invention belongs to the field of olfactory function detection products, in particular to the application of KIBRA rs17070145 detection reagent in the preparation of an olfactory function evaluation kit. Background technique [0002] The disclosure of information in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. [0003] Kidney and brain expressed protein (KIBRA), a postsynaptic protein encoded by the WWC1 gene, is involved in regulating neuronal synaptic plasticity and controlling organ size by regulating cell proliferation and apoptosis. KIBRA gene (Gene ID: 23286) is located on the long arm of chromosome 5 (5q34), and there is a common single nucleotide polymorphism (SNP) site in the ninth intron rs17070145...

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This study showed that the GMV of the prefrontal cortex and parahippocampal cortex of KIBRA C allele carriers was significantly lower than that of TT carriers, which in turn affected the cognitive function of the elderly; Dawei Wang et al. found that compared with TT genotype individuals , C allele carriers had significantly lower GMV and increased synchronization in the right medial prefrontal cortex and bilateral dorsal anterior cingulate cortex

[0005] However, whether KIBRA rs17070145 gene polymorphism can affect olfactory function by regulating brain structure has not been reported internationally

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