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Composition and application thereof in preparation of medicine with effect of treating stomach injury and/or gastric ulcer

A composition and technology of traditional Chinese medicine, applied in the application of medicine, the field of composition, can solve the problems such as insufficient conspicuousness, and achieve the effect of excellent treatment of gastric ulcer and gastric injury, and excellent effect of treatment of gastric ulcer and gastric injury

Active Publication Date: 2022-04-29
深圳海创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, natural products are not significant enough in the treatment of gastric ulcer and gastric injury

Method used

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  • Composition and application thereof in preparation of medicine with effect of treating stomach injury and/or gastric ulcer
  • Composition and application thereof in preparation of medicine with effect of treating stomach injury and/or gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 composition

[0032] The composition is obtained by uniformly mixing the Chinese medicine extract and the animal liver extract at a weight ratio of 5:1.

[0033] The Chinese medicine extract is prepared by the following method:

[0034] S11. Take 200g of the traditional Chinese medicine Poria cocos and grind it into a Soxhlet extractor, add 1L of ethanol aqueous solution with a volume fraction of 60%, conduct ultrasonic extraction for 2 hours, concentrate and dry the extract to obtain the organic solvent extract of Poria cocos;

[0035] S12. Put the Poria cocos organic solvent extract on the silica gel column (adopt 200-300 mesh silica gel column packing, the weight consumption of silica gel is 20 times of the Poria cocos organic solvent extract weight), first elute with ethyl acetate of 5 times column volume to obtain Ethyl acetate eluate (discard not need); After ethyl acetate elution, then elute with absolute ethanol of 5 times of col...

Embodiment 2

[0040] The preparation of embodiment 2 compositions

[0041] The composition is obtained by uniformly mixing the Chinese medicine extract and the animal liver extract at a weight ratio of 10:1.

[0042] The Chinese medicine extract is prepared by the following method:

[0043] S11. Take 200g of traditional Chinese medicine Poria cocos and grind it into a Soxhlet extractor, add 2L of ethanol aqueous solution with a volume fraction of 50%, conduct ultrasonic extraction for 1 hour, concentrate and dry the extract to obtain the organic solvent extract of Poria cocos;

[0044] S12. put the organic solvent extract of Poria cocos on a silica gel column (adopt 200-300 mesh silica gel to pack the column, the weight consumption of silica gel is 20 times of the weight of the organic solvent extract of Poria cocos), and first elute with ethyl acetate of 3 times the column volume to obtain Ethyl acetate eluent (discard not); after ethyl acetate elution, then elute with 6 times column volu...

Embodiment 3

[0049] The preparation of embodiment 3 compositions

[0050] The composition is obtained by uniformly mixing the Chinese medicine extract and the animal liver extract in a weight ratio of 3:1.

[0051] The Chinese medicine extract is prepared by the following method:

[0052] S11. Take 200g of the traditional Chinese medicine Poria cocos and put it into a Soxhlet extractor after pulverization, add 1.5L of ethanol aqueous solution with a volume fraction of 95%, ultrasonically extract for 1.5h, concentrate and dry the extract to obtain the organic solvent extract of Poria cocos;

[0053] S12. Put the Poria cocos organic solvent extract on the silica gel column (adopt 200-300 mesh silica gel column packing, the weight consumption of silica gel is 20 times of the Poria cocos organic solvent extract weight), first elute with ethyl acetate of 6 times column volume to obtain Ethyl acetate eluent (discard not need); After ethyl acetate elution, then elute with absolute ethanol of 3 tim...

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Abstract

The invention relates to the technical field of medicinal chemistry, and particularly discloses a composition and application thereof in preparation of a medicine for treating gastric injury and / or gastric ulcer. The composition comprises a traditional Chinese medicine extract and an animal liver extract. The traditional Chinese medicine extract is a poria cocos extract. The poria cocos extract is prepared by the following steps: S11, extracting a traditional Chinese medicine poria cocos with an organic solvent, and concentrating and drying an extracting solution to obtain a poria cocos organic solvent extract; s12, loading the poria cocos organic solvent extract on a silica gel column, and eluting with ethyl acetate to obtain ethyl acetate eluent; eluting with ethyl acetate, and then eluting with ethanol to obtain an ethanol eluent; and concentrating and drying the ethanol eluent to obtain the poria cocos extract. Researches show that the composition has excellent effects of treating gastric ulcer and stomach injury; therefore, the compound can be used as an effective component for developing medicines for treating gastric ulcer and gastric injury.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a composition and its application in the preparation of medicines capable of treating gastric damage and / or gastric ulcer. Background technique [0002] Gastric ulcer is one of the most common chronic gastrointestinal dysfunction diseases worldwide, with an incidence rate as high as 10%. Gastric ulcer is a multiple disease involving multiple factors and channels. Its main clinical manifestations are long-term periodic and rhythmic upper abdominal pain, accompanied by nausea, vomiting, regurgitation, belching, pantothenic acid and a series of gastrointestinal symptoms. tract symptoms. The fast pace of life, huge life and work pressure make drinking a part of people's daily life, but excessive drinking can lead to gastric mucosal damage and gastric ulcer. Ethanol, the main component in alcohol, can dissolve in lipids and enter the stomach wall, causing gastric mucosal...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61K35/407A61P1/00A61P1/04
CPCA61K36/076A61K35/407A61P1/00A61P1/04A61K2236/333A61K2236/51A61K2236/55A61K2300/00Y02A50/30
Inventor 刘杰牛文芳刘晓宇龚苗张帅罗丹罗强王怀玲
Owner 深圳海创生物科技有限公司
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