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Immobilized uricase perfusion device and application thereof

A technology of uricase and perfusion device, which is applied in the field of medical devices, can solve the problems that the perfusion device cannot exert its maximum function, the patient's satisfaction and compliance decrease, and the filter has thrombosis, so as to reduce the possibility of treatment risk, Improve the utilization of medical resources and reduce the effect of thrombosis

Active Publication Date: 2022-04-12
江苏恰瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] During clinical use, due to (1) some air is easily mixed into the column; (2) the blood flow in the pipeline is not smooth; (3) thrombus is formed in the column cavity or filter; (4) the blood viscosity of the patient is high; (5) Due to the physical properties of the filler adsorbent particles themselves, the blood often cannot fully and evenly contact with the adsorbent particles during hemoperfusion, resulting in the inability of the perfuser to exert its maximum function, prolonging the treatment time, increasing the risk of treatment, patient satisfaction and decreased compliance

Method used

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  • Immobilized uricase perfusion device and application thereof
  • Immobilized uricase perfusion device and application thereof
  • Immobilized uricase perfusion device and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A perfusator filled with immobilized uricase, comprising a packed column 13, a filter screen 7, a cap 6, a joint 5 and a C-shaped electromagnet 10, is characterized in that the two ends of the packed column 13 are respectively provided with a filter Net 7, two unconnected rotatable C-shaped electromagnets 10 are installed symmetrically on the outside of the filling column 13, the end of the filter screen 7 is provided with a cover 6, and the cover 6 is provided with a liquid inlet and outlet Interface 5;

[0036] Wherein, the immobilized uricase is filled into the packed column 13, and the filling amount is 1 / 2 of the volume of the packed column; the immobilized uricase is based on carboxylated ferric oxide particles as a carrier, and then the uricase is fixed on the particle surface made on

[0037] The particle size of the carboxylated ferric oxide particles is 0.3mm.

[0038] In this embodiment, bearings 8 are fixedly installed on the outer upper and lower parts of...

Embodiment 2

[0044] A perfusator filled with immobilized uricase, comprising a packed column 13, a filter screen 7, a cap 6, a joint 5 and a C-shaped electromagnet 10, is characterized in that the two ends of the packed column 13 are respectively provided with a filter Net 7, two unconnected rotatable C-shaped electromagnets 10 are installed symmetrically on the outside of the filling column 13, the end of the filter screen 7 is provided with a cover 6, and the cover 6 is provided with a liquid inlet and outlet Interface 5;

[0045] Wherein, the immobilized uricase is filled into the packed column 13, and the filling amount is 1 / 2 of the volume of the packed column; the immobilized uricase is based on carboxylated ferric oxide particles as a carrier, and then the uricase is fixed on the particle surface made on

[0046] The particle size of the carboxylated ferric oxide particles is 0.4mm.

[0047]In this embodiment, bearings 8 are fixedly installed on the outer upper and lower parts of ...

Embodiment 3

[0053] A perfusator filled with immobilized uricase, comprising a packed column 13, a filter screen 7, a cap 6, a joint 5 and a C-shaped electromagnet 10, is characterized in that the two ends of the packed column 13 are respectively provided with a filter Net 7, two unconnected rotatable C-shaped electromagnets 10 are installed symmetrically on the outside of the filling column 13, the end of the filter screen 7 is provided with a cover 6, and the cover 6 is provided with a liquid inlet and outlet Interface 5;

[0054] Wherein, the immobilized uricase is filled into the packed column 13, and the filling amount is 2 / 3 of the volume of the packed column; the immobilized uricase is based on carboxylated ferric oxide particles as a carrier, and then the uricase is fixed on the particle surface made on

[0055] The particle size of the carboxylated ferric oxide particles is 0.5 mm.

[0056] In this embodiment, bearings 8 are fixedly installed on the outer upper and lower parts o...

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Abstract

The invention discloses a perfusion device filled with immobilized uricase, which is characterized in that an immobilized enzyme adsorbent is filled into a pipe with filter screens at two ends, end sockets are arranged outside the filter screens, liquid inlet and outlet interfaces are arranged on the end sockets, and the immobilized uricase adopts carboxylated ferroferric oxide particles as a carrier and is filled into the perfusion device in the form of a packed column; two rotatable C-shaped electromagnets are mounted on the outer side of the perfusion device; the particle size of the carboxylated ferroferric oxide particles ranges from 0.2 mm to 0.5 mm. According to the perfusion device provided by the invention, carboxylated ferroferric oxide with magnetism and biocompatibility is selected as a filler adsorbent, and the material of the filler adsorbent is improved while the structure of the shell is optimized, so that blood is in full and complete contact with the filler adsorbent on the premise of not increasing clinical risks, the adsorption area is increased, and the adsorption efficiency is improved. The adsorption effect is enhanced, so that a better clinical curative effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an immobilized uricase perfusion device and an application thereof. Background technique [0002] Hemoperfusion is a blood purification technique that introduces the patient's blood into a perfusion device equipped with solid adsorbents, and removes exogenous or endogenous toxins, drugs or metabolic wastes in the blood that cannot be removed by dialysis through adsorption. It is mainly used to rescue drugs and toxic poisoning, and can also be used in combination with hemodialysis to remove macromolecular toxins in chronic renal failure patients undergoing maintenance dialysis. [0003] The general flow of the hemoperfusion process is as follows: two venous channels are opened, one is used for blood extraction, and the other is used for blood reinfusion, and the two venous channels are connected through a pipeline system. The patient's venous blood is drawn ou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
Inventor 顾凌巍陆雪峰张丁一
Owner 江苏恰瑞生物科技有限公司
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