Application of paeonol in preparation of medicine for treating obesity and lipotoxic cardiomyopathy

A technology of paeonol and cardiomyopathy, applied in the field of application of paeonol in the preparation of drugs for the treatment of obesity and lipotoxic cardiomyopathy, to achieve the effect of alleviating metabolic disorders

Pending Publication Date: 2022-04-12
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some studies have initially shown that paeonol has a protective effect on general myocardial cell damage (such as inflammation), but there is no literature report on whether it has a therapeutic effect on lipotoxic cardiomyopathy

Method used

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  • Application of paeonol in preparation of medicine for treating obesity and lipotoxic cardiomyopathy
  • Application of paeonol in preparation of medicine for treating obesity and lipotoxic cardiomyopathy
  • Application of paeonol in preparation of medicine for treating obesity and lipotoxic cardiomyopathy

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with specific examples, but the protection scope of the present invention is not limited thereto. It should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0028] 1. Materials

[0029] Paeonol (Paeonol, C 9 h 10 o 3, MW=166.18g / mol): 80mgPae was dissolved in 4ml of a mixed solvent (3.4ml of normal saline and 0.6ml of absolute ethanol, mixed), heated and mixed, and put into a thermos cup for later use. During the operation, the medicine is taken out from the thermos cup and then administered into the stomach after being slightly cooled at room temperature. When Pae is administered on the cells, 20 mg Pae is added to 1 ml DMSO (dimethyl sulfoxide) to prepare a 20 mg / ml moth...

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Abstract

The invention belongs to a novel application of paeonol, and particularly relates to an application of paeonol in preparation of medicines for treating obesity and lipotoxic cardiomyopathy. In a model of treating mouse obesity by paeonol, through animal characterization and oil red o staining of rat primary myocardial cells, the effect of paeonol in glycolipid metabolism change and heart lipid metabolism disorder caused in a mouse obesity model fed with high fat diet is researched. The results show that paeonol can alleviate glycolipid metabolism change and heart lipid toxicity caused by obesity induced by high fat diet. Paeonol may become a potential effective treatment method for heart lipotoxicity caused by obesity.

Description

technical field [0001] The invention belongs to the new application of paeonol, in particular to the application of paeonol in the preparation of medicaments for treating lipotoxic cardiomyopathy. The invention relates to the application of paeonol in the preparation of medicines for treating lipotoxic cardiomyopathy or lipotoxic myocardial injury induced by high-fat diet. Background technique [0002] In recent years, with the improvement of people's living standards, great changes have taken place in the diet structure. High sugar and high nutrients have become the main components of people's food, resulting in overnutrition and a large increase in the proportion of obesity. As the incidence of obesity increases, the incidence of cardiovascular system-related diseases also increases significantly. Obesity can cause high blood pressure, diabetes, high cholesterol, malignant tumors, etc., which can indirectly cause harm to the heart. Ventricular hypertrophy can lead to he...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K36/71A61K36/65A61P3/04A61P9/00
Inventor 叶俊梅杨青晨刘泽坤彭悦
Owner CHINA PHARM UNIV
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