Thermal protective agent of HMB, application of thermal protective agent, HMB derivative and application of HMB derivative

A heat protectant and derivative technology, which is applied in the fields of non-active ingredients medical preparations, food science, drug combinations, etc., can solve the problems of unsolved HMB deterioration, yellowing and odor, etc.

Pending Publication Date: 2022-04-05
NANTONG LICHENG BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it only masks the taste of β-hydroxy-β-methylbutyrate through a flavoring agent, and does not deal with the taste of HMB deteriorating by heat, and does not solve the problem of HMB deteriorating, yellowing and smelling

Method used

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  • Thermal protective agent of HMB, application of thermal protective agent, HMB derivative and application of HMB derivative
  • Thermal protective agent of HMB, application of thermal protective agent, HMB derivative and application of HMB derivative
  • Thermal protective agent of HMB, application of thermal protective agent, HMB derivative and application of HMB derivative

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] β-Hydroxy-β-methylbutyrate is currently mostly prepared in the form of tablets, and heating steps such as drying in the wet granulation process are likely to denature HMB. In some specific embodiments of the present invention, when the composition is a tablet, it includes the following parts by weight of raw materials: 3800-4200 parts of β-hydroxy-β-methylbutyrate, calcium carbonate 3800-4000 parts, 950-1050 parts of heat protection agent, 900-1000 parts of maltodextrin, 40-60 parts of magnesium stearate and 500-700 parts of water; preferably, the raw materials include β-hydroxy-β-formazan 3950-4050 parts of calcium butyrate, 3950-4050 parts of calcium carbonate, 980-1030 parts of magnesium malate, 920-1000 parts of maltodextrin, 45-55 parts of magnesium stearate and 550-650 parts of water. The preparation method of above-mentioned composition comprises the steps:

[0038] (4) pulverizing the raw materials except magnesium stearate and water, mixing the pulverized raw ...

Embodiment 1

[0050] Example 1 Composition Tablet 1 Containing HMB and Heat Stabilizer

[0051] The composition comprises the following raw materials: 4000g of calcium β-hydroxy-β-methylbutyrate, 4000g of calcium carbonate, 1000g of magnesium malate, 950g of maltodextrin, 50g of magnesium stearate and 600g of water.

[0052] (1) Use a 40-mesh sieve to sieve β-hydroxy-β-methyl calcium butyrate fine powder, calcium carbonate fine powder, magnesium malate fine powder, malt paste fine powder, magnesium stearate with D90≤380 microns fine powder for use;

[0053] (2) Add 4000g of the above-mentioned β-hydroxy-β-methyl calcium butyrate fine powder, 4000g of calcium carbonate fine powder, 1000g of magnesium malate fine powder, 950g of malt paste fine powder, 50g of magnesium stearate fine powder, and 600g of water In a high-speed mixer, the mixing time is 10 minutes, and the mixing temperature is 35°C to obtain a soft material;

[0054] (3) the above-mentioned soft materials are granulated by a w...

Embodiment 2

[0058] Example 2 Composition Tablet 2 Containing HMB and Heat Stabilizer

[0059] The composition comprises the following raw materials: 3950g of calcium β-hydroxy-β-methylbutyrate, 3950g of calcium carbonate, 950g of calcium malate, 900g of maltodextrin, 40g of magnesium stearate and 500g of water.

[0060] (1) Use a 40-mesh sieve to sieve β-hydroxy-β-methyl calcium butyrate fine powder, calcium carbonate fine powder, calcium malate fine powder, malt paste fine powder, magnesium stearate with D90≤380 microns fine powder for use;

[0061] (2) 3950g of the above-mentioned β-hydroxy-β-methyl calcium butyrate fine powder, 3950g of calcium carbonate fine powder, 950g of L-malic acid fine powder, 900g of malt paste fine powder, 40g of magnesium stearate fine powder, and 500g of water Add it to a high-speed mixer, mix for 5 minutes, and mix at a temperature of 25°C to make a soft material;

[0062] (3) the above-mentioned soft materials are granulated by a wet granulator, and 10 m...

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Abstract

The invention provides a thermal protective agent of beta-hydroxy-beta-methylbutyrate (HMB) and application of the thermal protective agent. The thermal protective agent comprises one or more of malic acid and salt thereof, tartaric acid and salt thereof, and fumaric acid and salt thereof. The HMB can be prevented from deterioration due to heating, and the bitter and astringent sour taste caused by deterioration due to heating of the HMB can be fundamentally eliminated. The invention also provides a beta-hydroxy-beta-methylbutyrate derivative which is generated by reaction of a thermal protective agent and beta-hydroxy-beta-methylbutyrate, is an HMB derivative reversible in reaction under an acidic condition, can be decomposed into HMB and the thermal protective agent again when encountering an acidic environment such as hydrochloric acid (gastric acid), and can be used as a novel HMB effective substance.

Description

technical field [0001] The invention relates to the technical field of food health products, in particular to a thermal protectant for HMB and its application, HMB derivatives and its application. Background technique [0002] β-hydroxy-β-methylbutyrate (β-hydroxy-β-methylbutyr–ate, HMB) is a five-carbon organic acid, which is an essential amino acid leucine in the body through its metabolite α-ketoisocaproic acid (α -ketoiso-caproicacid, a derivative produced by α-KIC). Leucine cannot be synthesized in the human body and must be ingested from the outside. β-Hydroxy-β-methylbutyric acid is often used in the form of salts such as calcium β-hydroxy-β-methylbutyrate, which can be used to promote muscle growth, enhance immunity, and reduce cholesterol and low-density lipoprotein (LDL) in the body Level to reduce the incidence of coronary heart disease and cardiovascular disease, but also enhance the body's ability to fix nitrogen, maintain protein levels in the body, widely us...

Claims

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Application Information

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IPC IPC(8): A61K47/12A61K31/19A61P37/04A61P3/06A61P3/02C07C69/675A23L33/00A23L29/00A23L29/30
Inventor 王济东巫佳丁丽丽季予陆星晨
Owner NANTONG LICHENG BIOLOGICAL ENG
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