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Preparation method of hemostatic patch

A technology of hemostatic patch and thrombin, which is applied in pharmaceutical formulations, devices for coating liquid on surfaces, coatings, etc., can solve problems such as waste of suspension, and achieve the effects of strong adhesion, good hemostatic effect and simple operation.

Pending Publication Date: 2022-03-29
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to ensure that the edge of the carrier is also coated with suspension, some suspension will be sprayed outside the carrier, resulting in waste of suspension

Method used

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  • Preparation method of hemostatic patch
  • Preparation method of hemostatic patch
  • Preparation method of hemostatic patch

Examples

Experimental program
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preparation example Construction

[0026] A kind of preparation method of hemostatic patch provided by the present invention, comprises the following steps:

[0027] (1), take a small amount of bovine collagen in the mold, and scrape it flat with a collagen scraper, so that the collagen forms a collagen layer with a thickness of 0.3-0.5cm on the mold; after removing the excess bovine collagen, press the film Paste the film on the surface of the scraped collagen layer. During the pasting process, avoid large air bubbles between the film and the collagen layer. Finally, freeze at 20-50°C for 19-23 hours, and remove the film. , The frozen collagen layer is used as the solid carrier of the hemostatic patch, also called collagen carrier.

[0028] (2) Mix fibrinogen, thrombin, calcium chloride and low-temperature absolute ethanol (pre-cooled at -20°C) to form a medicinal solution, and place it in a disperser (IKA, T 25 easy clean) for homogenization Stirring, the stirring speed in the process of homogenization is (1...

Embodiment 1

[0041] The preparation method of the hemostatic patch provided by the invention comprises the following steps:

[0042] (1) Put the square mold (made of medical grade PVC, size 4.9cm×4.9cm×1cm) into the 316 stainless steel liquid medicine tray, take a small amount of bovine collagen (transparent gel, do not process after purchase, use directly ) in the mould, scrape it flat with a collagen scraper (made of 316 stainless steel), so that the collagen forms a collagen layer with a thickness of 0.3-0.5 cm on the mould; Made of medical grade PVC) on the surface of the scraped collagen layer. During the pasting process, large air bubbles should be avoided between the pressure film and the collagen layer. 20°C gradient down to -50°C) freezing for 19-23h, peel off the pressure film, and the frozen collagen layer is used as the solid carrier of the hemostatic patch, also called collagen carrier.

[0043] Gradient freezing can specifically be as follows: the temperature drops from 20°C...

Embodiment 2

[0059] The present invention also prepared the following hemostatic composition examples, and verified the effect of the content of each substance in the hemostatic composition examples on the hemostatic patch through experiments.

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Abstract

The preparation method sequentially comprises the following steps: preparing a collagen carrier, preparing a suspension of a hemostatic composition, spraying the suspension on the surface of the collagen carrier to form a liquid medicine layer, freeze-drying the liquid medicine layer and the collagen carrier to form the hemostatic patch, and the like. The average diameter of the hemostatic composition particles in the suspension is 33-50 [mu] m (preferably 37-42 [mu] m), and the average value of the precipitation volume in 5 minutes is gt; 90% (preferably greater than or equal to 95%). The hemostatic patch prepared by the method is good in hemostatic effect, has good biocompatibility, can be completely degraded in vivo, does not need secondary debridement, avoids secondary injury to the wounded, can be applied to hemostasis (especially hemostasis of visceral hemorrhage) of the wounded under the conditions of various emergencies, natural disasters (especially intense earthquakes) and the like, and has a wide application prospect. The method has good commercial value and wide application prospect.

Description

technical field [0001] The invention relates to the technical field of preparation of medical hemostatic products, in particular to a preparation method of a hemostatic patch. Background technique [0002] Bleeding is one of the most common and difficult to control problems in surgery and trauma, especially the bleeding of important organs, such as liver, spleen, and kidney rupture and bleeding are often life-threatening. Traditional hemostasis methods (such as ligation and compression hemostasis) are only suitable for hemostasis of large blood vessel bleeding, and have limited hemostatic effect on diffuse bleeding and visceral bleeding. Trauma bleeding is also a major cause of death, and rapid and effective hemostasis after injury is the most important means to save the lives of the wounded and sick. [0003] However, when the body is severely injured, autologous blood coagulation is not enough to quickly coagulate blood, so it is necessary to add hemostatic materials to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/18A61L15/42A61L15/44A61L15/64B05B13/04B05D7/24
CPCA61L15/325A61L15/32A61L15/18A61L15/42A61L15/44A61L15/64B05B13/041B05D7/24A61L2400/04A61L2300/252A61L2300/254A61L2300/418C08L89/00
Inventor 马玉媛袁方贾俊婷张欢章金刚赵雄王强王东根付秋霞阎少多孙珍珠吕茂民皇甫超济王蕊
Owner ACADEMY OF MILITARY MEDICAL SCI
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