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Medicine for treating chronic kidney disease and application thereof

A technology of use and medicine, applied in the field of medicine, can solve the problem of no medicine that can effectively treat chronic kidney disease

Pending Publication Date: 2022-03-29
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In recent years, the incidence of chronic kidney disease has been on the rise, but there is still no drug that can effectively treat chronic kidney disease

Method used

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  • Medicine for treating chronic kidney disease and application thereof
  • Medicine for treating chronic kidney disease and application thereof
  • Medicine for treating chronic kidney disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Drug efficacy test of compound II in STZ-HFD-induced diabetic nephropathy model of C57BL / 6 mice Therapeutic effect.

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Abstract

The invention relates to a medicine for treating chronic kidney disease and application thereof, and belongs to the field of medicine. The invention provides application of a compound shown in a formula (I), especially a formula (II), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a hydrate thereof or a solvate thereof in preparation of a medicine for treating chronic nephrosis. Animal experiments in a C57BL / 6 mouse STZ-HFD induced diabetic nephropathy model prove that the compound II does not influence food intake and kidney weight in the process of treating chronic nephropathy, and serum urea and insulin are remarkably reduced; the traditional Chinese medicine composition can obviously relieve pathological changes such as reduction of the number of glomerular capillary plexus and capillaries, glomerular mesangial hyperplasia, matrix precipitation and the like, and the score of glomerular sclerosis is obviously reduced. The test data shows that the compound II can effectively treat chronic nephropathy, especially diabetic nephropathy, and an unexpected technical effect is achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to medicine for treating chronic kidney disease and its application. Background technique [0002] Chronic kidney disease (CKD) refers to the abnormal structure or function of the kidneys for more than 3 months, which affects health. Chronic kidney disease is a clinical collective term for primary kidney disease, various secondary kidney diseases, and various congenital and hereditary kidney diseases. The common manifestations are hematuria, proteinuria, edema, and hypertension. In recent years, with the increase in the incidence of diabetes, hypertension, obesity, etc. and the influence of population aging and other factors, the incidence of chronic kidney disease in my country has increased significantly, seriously threatening human health. According to the epidemiological survey data in recent years, the incidence rate of chronic kidney disease in my country is 9.4% to 12.1%. [0003] D...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61P13/12A61P3/10
CPCA61K31/4439A61P13/12A61P3/10
Inventor 黄圣健鲁先平潘德思杨千姣
Owner SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD
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