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Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating inflammatory bowel disease

A technology for inflammatory bowel disease and drugs, applied in the field of medicine, can solve the problems of prevention or treatment of inflammatory bowel disease with Lycium barbarum glycopeptide, achieve important social benefits and economic value, reduce acute colitis symptoms, and reduce inflammatory reactions Effect

Active Publication Date: 2022-03-22
NINGXIA QIPEPTIDE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the prevention or treatment of inflammatory bowel disease with Lycium barbarum glycopeptide

Method used

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  • Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating inflammatory bowel disease
  • Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating inflammatory bowel disease
  • Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0045] Example: Daily intragastric administration of lycium glycopeptide in the treatment of DSS-induced ulcerative colitis

[0046] by e.g. figure 1 The indicated methods were grouped and established a DSS-induced mouse acute colitis model.

[0047] In this pharmacodynamic study, Student's t-test and Welch's t-test were used to analyze the data between the two groups. Data from more than two groups were analyzed by one-way analysis of variance (ANOVA) followed by Tukey's multiple comparison test. Graphpad Prism 9 (version 0.1.1) and R Studio (version 1.4.1106) were used for statistical analysis. All data are presented as mean ± SEM. P<0.05 was considered statistically significant. Among them, *P<0.5, **P<0.05, ***P<0.005, ****P<0.0001.

[0048] 6-8 week old C57BL\6 mice (purchased from Beijing Huafukang Biotechnology Co., Ltd.) were used and randomly divided into three groups with 15 mice in each group before modeling. The first group was the control group (Control); th...

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Abstract

The invention belongs to the field of medicines, and particularly relates to application of lycium barbarum glycopeptide in preparation of medicines for preventing or treating inflammatory bowel diseases. Experimental results of a dextran sodium sulfate (DSS)-induced mouse acute ulcerative colitis model show that the Chinese wolfberry glycopeptide can significantly advance the chronic remission period, significantly alleviate the acute colitis symptom, effectively reduce inflammatory response, and show an obvious anti-inflammatory effect. The experimental results show that the lycium barbarum glycopeptide as a traditional Chinese medicinal material extraction product can be effectively used for preventing and treating the inflammatory bowel disease, has the prospect of being developed into the medicine for preventing and treating the inflammatory bowel disease, provides more treatment choices for clinically preventing or treating the inflammatory bowel disease, and has important social benefits and economic values.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the use of lycium barbarum glycopeptide in the preparation of a medicament for preventing or treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic nonspecific intestinal mucosal involvement of the ileum, rectum and colon Inflammatory disease, the course of which is repeated, clinically mainly manifested as abdominal pain, diarrhea, mucus pus and bloody stool, and tenesmus. The patient's quality of life deteriorates significantly, and patients often require lifelong medication or even surgery. [0003] Epidemiological studies have found that the incidence of IBD is relatively high in North America and Northern Europe, but the incidence has gradually increased in the Asia-Pacific region in recent years. Among them, China has become one of the countries with the highest in...

Claims

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Application Information

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IPC IPC(8): A61K38/14A61P29/00A61P1/00A61P1/04
CPCA61K38/14A61P29/00A61P1/00A61P1/04
Inventor 秦蒙黄鲁黄翊淳郑颖慧苏国辉张力肖佳于哲雄王金霞樊福
Owner NINGXIA QIPEPTIDE TECH CO LTD
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