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Preparation and application of phloretin-loaded soybean lecithin-chitosan nanoparticles for preventing diabetes

A soybean lecithin and chitosan nanotechnology, which can be used in urinary system diseases, medical preparations with inactive ingredients, metabolic diseases, etc., can solve the problems of low bioavailability, poor water solubility, poor light stability, etc., and achieve improvement Water solubility, expanding application prospects, strong α-glucosidase inhibitory effect

Active Publication Date: 2022-03-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Phloretin has also been proven to be an effective SGLT2 inhibitor, but due to its poor water solubility, poor light stability, and low bioavailability, the application and development of phloretin in food, medicine, and cosmetics has been greatly restricted. hinder

Method used

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  • Preparation and application of phloretin-loaded soybean lecithin-chitosan nanoparticles for preventing diabetes
  • Preparation and application of phloretin-loaded soybean lecithin-chitosan nanoparticles for preventing diabetes
  • Preparation and application of phloretin-loaded soybean lecithin-chitosan nanoparticles for preventing diabetes

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Embodiment 1

[0053] Embodiment 1, the preparation of phloretin nanoparticles, may further comprise the steps:

[0054] 1), get 1g chitosan and dilute to 100mL with 1% (v / v) acetic acid aqueous solution, and make chitosan dissolve, be mixed with 1% (w / v, namely 1g / 100ml) chitosan mother liquor, measure Take 2mL chitosan mother liquor and add 16.4mL deionized water to dilute, as the water phase;

[0055] 2) Weighing 50 mg of soybean lecithin and dissolving it in 1.6 mL of absolute ethanol to obtain a soybean lecithin ethanol solution; accurately weighing 5 mg of phloretin to fully dissolve it in the soybean lecithin ethanol solution as the ethanol phase;

[0056] 3) Under the condition of magnetic stirring, inject the ethanol phase obtained in step 2) into the water phase obtained in step 1), therefore, 20 mL of the fixed system.

[0057] At a rotational speed of 400 r / min, after magnetic stirring for 2 h, the pH was adjusted to 4 with 1 mol / L HCl and NaOH to obtain a soybean lecithin-chito...

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Abstract

The invention discloses a preparation method of phloretin-loaded soybean lecithin-chitosan nanoparticles, which comprises the following steps: dissolving chitosan in an acetic acid aqueous solution to prepare a chitosan mother solution; adding deionized water into the chitosan mother liquor to dilute the chitosan mother liquor to obtain a water phase; weighing phloretin, and dissolving phloretin in the soybean lecithin ethanol solution to serve as an ethanol phase; injecting the ethanol phase into the water phase under a magnetic stirring condition; after magnetic stirring, the pH is adjusted, and a phloretin-loaded soybean lecithin-chitosan nanoparticle solution is obtained. The soybean lecithin-chitosan nanoparticle solution loaded with phloretin or the phloretin nanoparticles prepared from the soybean lecithin-chitosan nanoparticle solution loaded with phloretin can be used for preparing drugs for treating diabetic kidney.

Description

technical field [0001] The invention relates to the application of soybean lecithin-chitosan nanoparticles loaded with phloretin in the protection of diabetic kidneys. Background technique [0002] Phloretin (Pht) belongs to the dihydrochalcone compounds, and is mainly found in plants such as polyacrylox, camellia, Vitex, strawberry, and wolfberry. Phloretin has been listed as a generally recognized safe substance (#4390) in the American Flavor and Extract Manufacturers Association; it has been evaluated as no safety problem (#2022) in the Joint Expert Committee on Food Additives. The median lethal dose (Median Lethal Dose, LD50) > 2000mg / kg bw; it is allowed to be used as a spice (#N376) in the "National Food Safety Standard Food Additives Use Standard" (GB 2760-2014), and there is no clear dosage regulation . Phloretin is not only safe and non-toxic, but also has physiological functions such as antibacterial, anti-oxidation, tyrosinase inhibition, hypoglycemic, anti-c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19
CPCA61K9/19A61K47/36A61K47/61A61K47/10A61K31/12A61P3/10A61P13/12
Inventor 沈建福夏琛吴晓琴
Owner ZHEJIANG UNIV
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