Method for extracting hesperidin

Abstract

The invention discloses a method for extracting hesperidin. The method comprises the following steps: (1) crushing; (2) impurity removal: putting the immature bitter orange powder into an extraction tank, adding a sodium carbonate solution, stirring to remove impurities, and collecting solids; (3) washing; (4) extraction: putting the washed solid into an extraction tank, adding an extraction solvent, stirring, and collecting an extracting solution; (5) adjusting acid and crystallizing; (6) filtering; and (7) drying the crystal to obtain a hesperidin product. The method is simple and convenient to operate, the impurity removal and extraction time is shortened to 2.5-4.0 hours from 48 hours of the conventional method, the energy consumption is low, the productivity is doubled under the condition of not increasing plants and equipment, the operability is strong, and the method is particularly suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting hesperidin, in particular to a method for extracting hesperidin with high production efficiency. Background technique [0002] Hesperidin (hesperidin) is generally extracted from the physiological fruit drop of Citrus aurantium or citrus peel during the growth of citrus. [0003] In view of the seasonality of citrus results, fresh fruits are generally collected and stored in the sun. Citrus is mainly distributed in provinces such as Huguang, Shaanxi, Sichuan and Guizhou in my country, and the quality is best in Hunan. [0004] Hesperidin belongs to dihydroflavonoids, and its pharmacological effects are as follows: Clinically, it is used in combination with vitamin C to treat various bleeding disorders caused by increased vascular fragility. Hesperidin can excite frog hearts in vitro and in situ. Intravenous injection of hesperidin can enhance the contractility of the rabbits in situ, but has little ef...

AI Technical Summary

Problems solved by technology

This method uses sodium citrate to remove impurities. Since hesperidin is extracted with lye, impurities such as hesperidin, naringin, isonaringin will be extracted at the same time, and sodium citrate theoretically It is impossible to remove impurities similar to hesperidin substances, only impurities such as colloids can be removed, the resulting product is unqualified, the purity and yield are low, and the method takes a long time to operate and the production efficiency is low

[0009] At present, the large-scale production of hesperidin has problems such as high difficulty, low yield, long cycle, difficult industrialization or very thin profits after industrialization.