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A kind of biological scaffold, its molding method and application

A bio-stent and molding method technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of high energy consumption, poor promotion, complicated devices, etc., and achieve the effect of reducing production cost and production difficulty, and easy operation

Active Publication Date: 2022-07-19
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the above methods, it is necessary to accurately control the moving speed of the product and the temperature of the container, and there are disadvantages such as high energy consumption, complicated devices, and complicated processes, and the promotion is poor.

Method used

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  • A kind of biological scaffold, its molding method and application
  • A kind of biological scaffold, its molding method and application
  • A kind of biological scaffold, its molding method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The present embodiment provides a method for forming a biological scaffold, comprising the following steps:

[0035] (1) mix the acid-soluble collagen dry powder, chitosan dry powder and hyaluronic acid dry powder, and swell in 0.05mol / L acetic acid aqueous solution to obtain raw material slurry; wherein, the total amount of acid-soluble collagen and chitosan is The concentration is 3 wt.%, and the concentration of hyaluronic acid is 0.1 wt.%;

[0036] (2) Use liquid nitrogen to pre-freeze the raw material slurry, and transfer the raw material slurry to the cylindrical metal mold 1 by injection, and lower the entire metal mold to the upper surface of the liquid nitrogen 2mm, without control Decrease the speed and stay for 15 minutes to keep the entire metal mold at a constant temperature, and pre-freeze the biological scaffold after completion;

[0037] (3) drying the pre-frozen biological scaffold, and the drying includes 5 stages in turn, which are:

[0038] (1) Und...

Embodiment 2

[0045] The present embodiment provides a method for forming a biological scaffold, comprising the following steps:

[0046] (1) mix the acid-soluble collagen dry powder and chondroitin sulfate dry powder, and swell in 0.05mol / L acetic acid aqueous solution to obtain raw material slurry; wherein, the concentration of acid-soluble collagen is 10wt. The concentration is 2wt.%;

[0047] (2) Use liquid nitrogen to pre-freeze the raw material slurry, and transfer the raw material slurry to the circular tubular metal mold 2 by injection, and lower the entire metal mold to the upper surface of the liquid nitrogen 20mm, without control Decrease the speed and stay for 120min to keep the entire metal mold at a constant temperature. After completion, take out and pull out the central column 3 to obtain a pre-freezing biological scaffold;

[0048] (3) drying the pre-frozen biological scaffold, and the drying includes 5 stages in turn, which are:

[0049] (1) Under the condition of -35℃, ...

Embodiment 3

[0056] The present embodiment provides a method for forming a biological scaffold, comprising the following steps:

[0057] (1) Mix chitosan dry powder and dermatan sulfate dry powder, and swell in 0.05mol / L acetic acid aqueous solution to obtain raw material slurry; wherein, the concentration of chitosan is 7wt.%, and the concentration of dermatan sulfate is 1wt.% ;

[0058] (2) Use liquid nitrogen to pre-freeze the raw material slurry, transfer the raw material slurry to a cylindrical metal mold by injection, and lower the entire metal mold to 10mm on the upper surface of the liquid nitrogen without controlling the drop speed, and stay for 70min to keep the entire metal mold at a constant temperature, and pre-freeze the biological scaffold after completion;

[0059] (3) drying the pre-frozen biological scaffold, and the drying includes 5 stages in turn, which are:

[0060] (1) Under the condition of -35℃, freeze for 15min;

[0061] (2) Freeze-drying for 830min at -9℃ and ...

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Abstract

The present invention relates to a biological scaffold, its forming method and application. The forming method of the biological scaffold includes: mixing degradable biological materials with glycosaminoglycans, and swelling them in an acetic acid aqueous solution to obtain a raw material slurry; using a refrigerant to pre-freeze the raw material slurry, and passing the raw material slurry through the The cooling effect is controlled by the distance from the refrigerant, and the pre-freezing biological scaffold is obtained after completion; the pre-frozen biological scaffold is then dried, and the biological scaffold is obtained after completion. The preparation method of the biological scaffold can achieve the effect of controlling the pre-freezing rate only by adjusting the distance, thereby obtaining biological scaffolds with different pore shapes, which can meet different application scenarios, the operation is extremely simple, and the production cost is reduced. and production difficulty; and the performance indicators of the obtained products meet the requirements.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a biological scaffold, a molding method and application thereof. Background technique [0002] With the development of science and technology, biological materials are changing with each passing day. Chinese patent CN101264350B discloses a method for preparing spinal cord duct membrane, which is specifically: making collagen into a certain concentration of collagen suspension, injecting it into an open mold, and freezing it vertically at a slow speed of 1 to 2 mm / min in - Within 80~-100℃, the product will be formed after secondary freezing. In addition, Chinese patent document CN101332134B discloses a collagen scaffold product with single longitudinally arranged pores using a freeze-drying process. The method is to make type I collagen into a suspension of a certain concentration, and then put it into a specific mold, and use 1- Vertical freezing at a speed of 2 ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/56A61L27/26A61L27/24
CPCA61L27/60A61L27/56A61L27/26A61L27/24A61L2430/32A61L2430/10C08L5/08C08L89/00
Inventor 张伊骁张伟孙冰冰
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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