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Radix tetrastigme spray liquid crystal gel for oral ulcer and preparation method thereof

A technology for oral ulcers and cloverleaf, which is applied to the field of cloverleaf spray liquid crystal gel for oral ulcers and its preparation field, can solve the problems that the efficacy of cloverleaf can not be well exerted, and is not suitable for the treatment of oral ulcers, etc. Convenient and safe administration, no immunogenicity, good fluidity

Pending Publication Date: 2022-03-11
浙江仲兴生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The Chinese invention patent with the patent number 201910188013.9 discloses a three-leaf green wound healing ointment and its preparation method. The prepared three-leaf green wound healing ointment can effectively inhibit the growth of bacteria around the wound, thereby achieving anti-inflammatory, antibacterial, and anti-inflammatory effects. However, the three-leaf green wound healing ointment provided by this method needs to be applied to the wound surface, and is not suitable for the treatment of oral ulcers.
[0004] The Chinese Invention Patent No. 201310067869.3 discloses Clover clover for treating ulcers, and provides a medicine for treating ulcers prepared with Clover clover, which is taken internally or / and externally. The medicinal effect of green

Method used

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  • Radix tetrastigme spray liquid crystal gel for oral ulcer and preparation method thereof
  • Radix tetrastigme spray liquid crystal gel for oral ulcer and preparation method thereof
  • Radix tetrastigme spray liquid crystal gel for oral ulcer and preparation method thereof

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preparation example Construction

[0035] The preparation method of described a kind of clover spray liquid crystal gel that is used for oral ulcer, comprises the following steps:

[0036] (1) Stir the phospholipids, natural fatty acid glycerides, and biocompatible solvents at room temperature until they are completely dissolved at room temperature, at a stirring speed of 800±400rpm, and for a stirring time of 20-25min, to obtain an oily mixed solution;

[0037] (2) Add the Cloverleaf extract in the mass percent into the mixed solution obtained in step (1), stir and disperse for 15-20 minutes to obtain the Cloverleaf spray liquid crystal gel.

Embodiment 1

[0039] A clover spray liquid crystal gel for oral ulcers, prepared from the following raw materials in mass percentage:

[0040] Clover extract 5%;

[0041] Soy Lecithin 40%;

[0042] Diolein 40%;

[0043] Tween-80 8%;

[0044] Ethanol 7%;

[0045] (1) Stir soybean lecithin, glyceryl dioleate, Tween-80 and ethanol at room temperature until they are completely dissolved at room temperature, at a stirring speed of 800±400rpm, and for 20 to 25 minutes, to obtain an oily mixed solution ;

[0046] (2) Add the Cloverleaf extract in the mass percent into the mixed solution obtained in step (1), stir and disperse for 15-20 minutes to obtain the Cloverleaf spray liquid crystal gel.

Embodiment 2

[0048] A clover spray liquid crystal gel for oral ulcers, prepared from the following raw materials in mass percentage:

[0049] Clover extract 8%;

[0050] Soy Lecithin 35%;

[0051] Alpha-Tocopherol 45%;

[0052] Tween-80 5%;

[0053] Ethanol 7%;

[0054] (1), stir the soybean lecithin, α-tocopherol, Tween-80 and ethanol at room temperature until completely dissolved at room temperature, the stirring speed is 800±400rpm, and the stirring time is 20~25min, to obtain an oily mixed solution;

[0055] (2) Add the Cloverleaf extract in the mass percent into the mixed solution obtained in step (1), stir and disperse for 15-20 minutes to obtain the Cloverleaf spray liquid crystal gel.

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Abstract

The invention discloses radix tetrastigme spray liquid crystal gel for oral ulcer. The radix tetrastigme spray liquid crystal gel is prepared from the following raw materials in percentage by mass: 1-10% of a radix tetrastigme extract, 20-50% of phospholipid, 20-50% of natural fatty glyceride and / or tocopherol and 5-30% of a biocompatible solvent, compared with the prior art, the tetrastigma hemsleyanum spray liquid crystal gel is moderate in viscosity and good in flowability, can quickly form liquid crystal gel when encountering a small amount of water, can immediately form liquid crystal gel after being sprayed to an ulcer, is short in gel forming time, does not change along with the change of the body temperature of a human body, is stable in structure, and can stably form a layer of protective film on a wound surface; the gel has good mucous membrane adhesion and lubricity, can effectively resist external stimulation, avoid bacterial infection, moisten wound parts and accelerate the healing process, and is convenient and safe in administration.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a liquid crystal gel sprayed with cloverleaf for oral ulcers and a preparation method thereof. Background technique [0002] Clover clover, also known as clover clover, is a rare medicinal plant unique to my country, and its roots or whole plants are used as medicine. [0003] The Chinese invention patent with the patent number 201910188013.9 discloses a three-leaf green wound healing ointment and its preparation method. The prepared three-leaf green wound healing ointment can effectively inhibit the growth of bacteria around the wound, thereby achieving anti-inflammatory, antibacterial, and anti-inflammatory effects. It has the effects of swelling, removing putrefaction and promoting granulation, and rapid wound healing, but the cloverleaf wound healing ointment provided by this method needs a wound coating film when used, and is not suitable for the treatment of or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K36/87A61K47/24A61P1/02
CPCA61K36/87A61K9/006A61K47/24A61P1/02
Inventor 李青坡钟洪伟姜新东钟铠瑞
Owner 浙江仲兴生物医药科技有限公司
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