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Application of tormentic acid and anisodamine capsule in preparation of medicine for treating diabetes

A technology of potentate acid and anisodamine, which is applied in capsule delivery, drug combination, metabolic diseases, etc., can solve the problems of slow drug dissolution rate and reduced drug efficacy, and achieve good dissolution, improved adaptability, and high stability Effect

Active Publication Date: 2022-02-18
江西金思康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to methods for improving insulin therapy that uses certain chemical compounds called combretastatin A (CSA) or its analogues like honokiol. These techniques aim to enhance glucose metabolism while reducing side effects such as weight gain due to increased body mass loss associated with poor glycaemics treatment.

Problems solved by technology

This patented technical problem addressed by this inventors relates to improving the compatibility between different components when making medicines containing these substances for better therapeutic benefits without causing unwanted side reactions during storage periods due to interaction caused by pH differences at certain points along their chemical structure.

Method used

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  • Application of tormentic acid and anisodamine capsule in preparation of medicine for treating diabetes
  • Application of tormentic acid and anisodamine capsule in preparation of medicine for treating diabetes
  • Application of tormentic acid and anisodamine capsule in preparation of medicine for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of potentate and anisodamine capsule preparation, its prescription is composed as follows:

[0030]

[0031] The preparation method is as follows:

[0032] (1) Preparation of Pollentinic Acid Granules: Take Potentateic Acid, Microcrystalline Cellulose, and Croscarmellose Sodium by weight, each pass through a 100-mesh sieve, add a certain amount of 3% PVP K30 aqueous solution and mix Post-wet granulation.

[0033] (2) Preparation of anisodamine granules: take anisodamine, lactose, mannitol, and crospovidone by weight, each pass through a 100-mesh sieve, add a certain amount of 5% hypromellose aqueous solution, mix and wet French granulation.

[0034] (3) Pollentinic acid granules and anisodamine granules are mixed according to a mass ratio of 1:1, and then filled into capsules.

Embodiment 2

[0036] A kind of potentate and anisodamine capsule preparation, its prescription is composed as follows:

[0037]

[0038] The preparation method is as follows:

[0039] (1) Preparation of Pollentinic Acid Granules: Take Potentateic Acid, Microcrystalline Cellulose, and Croscarmellose Sodium by weight, each pass through a 100-mesh sieve, add a certain amount of 3% PVP K30 aqueous solution and mix Post-wet granulation.

[0040] (2) Preparation of anisodamine granules: take anisodamine, lactose, mannitol, and crospovidone by weight, each pass through a 100-mesh sieve, add a certain amount of 5% hypromellose aqueous solution, mix and wet French granulation.

[0041] (3) Pollentinic acid granules and anisodamine granules are mixed according to a mass ratio of 1:0.5, and then filled into capsules.

Embodiment 3

[0043] A kind of potentate and anisodamine capsule preparation, its prescription is composed as follows:

[0044]

[0045] The preparation method is as follows:

[0046] (1) Preparation of Pollentinic Acid Granules: Take Potentateic Acid, Microcrystalline Cellulose, Lactose, and Croscarmellose Sodium by weight, each pass through a 100-mesh sieve, and add a certain amount of 3% PVP K30 The aqueous solution is mixed and then wet granulated.

[0047] (2) Preparation of anisodamine granules: take anisodamine, lactose, and crospovidone by weight, each pass through a 100-mesh sieve, add a certain amount of 3% hypromellose aqueous solution, and wet granulate after mixing .

[0048] (3) Pollentin granules and anisodamine granules are mixed according to a mass ratio of 1:0.8, and then filled into capsules.

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Abstract

The invention relates to the field of pharmaceutical preparations, and provides a tormentic acid and anisodamine capsule and a preparation method thereof. Tormentic acid and anisodamine are respectively used to prepare acid particles and alkali particles, and mutual reaction of the tormentic acid and the anisodamine is avoided. By adopting a capsule filling form, the ratio of tormentic acid and anisodamine can be well controlled. The tormentic acid and the anisodamine are combined for use, so that a synergistic blood sugar reducing effect is achieved, and the prepared medicine capsule has good patient adaptability. The structure of the tormentic acid is shown in the specification.

Description

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Claims

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Application Information

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Owner 江西金思康药业有限公司
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