Application of quercetin in preparation of medicine for treating intervertebral disc nucleus pulposus degeneration

A technology of intervertebral disc and quercetin, which is applied in the application field of quercetin in the preparation of drugs for the treatment of intervertebral disc nucleus pulposus degeneration, to achieve the effect of maintaining normal shape and function, protecting nucleus pulposus cell damage, and weakening nucleus pulposus cell damage

Pending Publication Date: 2022-02-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for the degeneration of the intervertebral disc, especially the nucleus pulposus cells, there is no relevant report on applying quercetin to prevent the degeneration of the nucleus pulposus of the intervertebral disc

Method used

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  • Application of quercetin in preparation of medicine for treating intervertebral disc nucleus pulposus degeneration
  • Application of quercetin in preparation of medicine for treating intervertebral disc nucleus pulposus degeneration
  • Application of quercetin in preparation of medicine for treating intervertebral disc nucleus pulposus degeneration

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Embodiment Construction

[0025] The present invention will be further described below in conjunction with specific examples, but the examples are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0026] 1. Quercetin (QUE) is used to treat the degeneration of the nucleus pulposus of the intervertebral disc.

[0027] 2. The rat nucleus pulposus cells were treated with 100 μM tert-butyl hydroperoxide (TBHP) to make a TBHP-induced oxidative stress injury model. The best therapeutic effect of quercetin at 60 μM was verified by CCK8 experiment. Finally, through the rat intervertebral disc organ culture model, the isolated intervertebral discs wer...

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Abstract

The invention discloses application of quercetin in preparation of a medicine for treating intervertebral disc nucleus pulposus degeneration. Tests prove that quercetin has an obvious effect of protecting nucleus pulposus cells from being damaged. In a rat nucleus pulposus cell apoptosis model of 100microM of TBHP, quercetin can obviously weaken nucleus pulposus cell damage caused by TBHP and maintain normal forms and functions of nucleus pulposus cells; quercetin has low toxicity to nucleus pulposus cells, and almost has no cytotoxicity within 200microM; quercetin can be used for remarkably relieving oxidative stress, degeneration and apoptosis of TBHP-induced nucleus pulposus cells of rats; according to the invention, new application of quercetin is developed, the use value of quercetin is improved, and theoretical support is provided for application of quercetin in preparation of drugs for preventing intervertebral disc degeneration.

Description

technical field [0001] The invention belongs to the technical field of new application of medicines, and in particular relates to the application of quercetin in the preparation of medicines for treating degeneration of intervertebral disc nucleus pulposus. Background technique [0002] Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain (LBP) in modern society, and it brings serious physical, psychological and economic burdens to people. Early studies mainly focused on biomechanics and inflammatory pathology. In recent years, scholars have begun to pay attention to the relationship between the energy metabolism of the nucleus pulposus and the rhythm of the biological clock and the occurrence of degeneration. Although there are many studies on the mechanism of IVDD and a lot of progress has been made, the specific mechanism is still not very clear. At present, the curative effect of non-surgical treatment is not clear. Most patients still need...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P19/08
CPCA61K31/352A61P19/08
Inventor 杨柳王栋罗卓荆贺欣彭盼睇徐小龙高博
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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