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Method for preparing dopamine and derivative thereof by utilizing agricultural and forestry wastes and special equipment thereof

A technology of agricultural and forestry waste and dopamine, which is applied in the preparation of organic compounds, preparation of amino hydroxyl compounds, chemical instruments and methods, etc., can solve the problems of unsatisfactory utilization, difficulty in concentration, and low added value of products, and achieve high added value The effect of high value utilization, purity and yield

Inactive Publication Date: 2022-02-01
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking straw as an example, although the production of bioethanol, biogas, feed and other technologies from straw have been developed, as well as the technology of cultivating edible fungus with straw, the utilization status is not ideal due to the low added value of the product, and it is affected by agricultural and forestry waste. It is difficult to use on a large scale due to problems such as high transportation costs and difficulty in concentration

Method used

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  • Method for preparing dopamine and derivative thereof by utilizing agricultural and forestry wastes and special equipment thereof
  • Method for preparing dopamine and derivative thereof by utilizing agricultural and forestry wastes and special equipment thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Take 50g of sawdust, add 28mL of 37 wt% hydrochloric acid and 400mL of methanol, react at 70°C and normal pressure for 72h, filter the reaction solution, evaporate to remove methanol, add ice deionized water, and dry the precipitate to obtain Product A;

[0049] Add 12mL of 70wt% sulfuric acid and 6mL of ethylene glycol to product A, acidolysis reaction at 150°C with an initial pressure of 1MPa nitrogen (as a protective gas) for 2h, filter the reaction solution, and evaporate to extract 3.31g of product B , ethylene glycol is used to protect the aldehyde group during the reaction;

[0050] Add 6wt% sulfuric acid and 0.1 g of Ru / C deprotection catalyst to product B, react for 1 h at 120°C and fill with nitrogen gas (as a protective gas) with an initial pressure of 0.1 MPa, filter the reaction solution, and evaporate to extract product C 2.99g;

[0051] Dissolve product C in p-xylene solvent, add 0.1 g of Ru / hydroxyapatite graft catalyst and ammonia gas with an initial ...

Embodiment 2

[0054] Take 50g of straw, add 30 mL of 70 wt% hydrochloric acid and 500 mL of ethanol, react at 78 °C and normal pressure for 48 hours, filter the reaction solution, evaporate to remove methanol, add ice deionized water, and dry the precipitate Product A is obtained;

[0055] Add 12mL of 70wt% sulfuric acid and 6mL of ethylene glycol to product A, react at 150°C and 1MPa initial pressure of nitrogen for 2h, filter the reaction solution, and evaporate to extract 4.46g of product B;

[0056] Add 6wt% sulfuric acid and 0.1 g of Ru / C deprotection catalyst to product B, react for 1 h at 120 ° C, initial pressure of 0.1 MPa nitrogen, filter the reaction solution, and evaporate to extract 3.97 g of product C;

[0057] Dissolve product C in p-xylene solvent, add 0.1g of Ru / hydroxyapatite graft catalyst and ammonia gas with initial pressure of 0.2MPa, and nitrogen gas with initial pressure of 0.8MPa to adjust the pressure, at 200°C After reacting for 8h, the reaction solution was filt...

Embodiment 3

[0060] Take 50g of sawdust, add 28mL of 37wt% hydrochloric acid and 400mL of methanol, react at 70°C and normal pressure for 72h, filter the reaction solution, evaporate to remove methanol, add iced deionized water, and dry the precipitate to obtain the product A;

[0061] Take 5 g of product A, add 1 mL of trifluoromethanesulfonic acid and 6 mL of ethanedithiol, react for 3 hours at 120 °C under normal pressure, filter the reaction solution, and evaporate to extract 2.45 g of product B;

[0062] Add 12wt% sulfuric acid and Ru / C to product B 3 N 4 Deprotection catalyst 0.1g, reacted at 120°C and initial pressure of 0.1MPa nitrogen for 1h, filtered the reaction solution, and evaporated to extract 2.23g of product C;

[0063] The product C was dissolved in p-xylene solvent, CH 2 =CH 2 Nucleophile 2mL, Ru / CeO 2 Graft catalyst 0.1g, react at 200°C for 8h, filter the reaction solution, and evaporate to extract 1.81g of product D;

[0064] Add water 10mL, Nb 2 o 5 Hydrolysis...

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Abstract

The invention discloses a method for preparing dopamine and a derivative thereof by utilizing agricultural and forestry wastes and special equipment thereof, and belongs to the field of medicine preparation. The method comprises the following steps: mixing the forestry and agricultural residues with an acid a and an extracting agent, and reacting to obtain a product A; mixing the product A with a hydrogen source a and a protective agent, and reacting to obtain a product B; mixing the product B with a de-protecting agent, and reacting to obtain a product C; adding a nucleophilic grafting reagent into the product C, and carrying out nucleophilic grafting reaction to obtain a product D; and hydrolyzing and hydrogenating the product D to obtain the dopamine or the dopamine derivative. The agricultural and forestry waste is used as the main raw material and is prepared into the dopamine and the derivative thereof so that high value-added utilization of the agricultural and forestry waste is realized, the yield of the prepared dopamine and the derivative thereof is relatively high, and a new thought is developed for high-value utilization of the agricultural and forestry waste.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a method and special equipment for preparing dopamine and its derivatives from agricultural and forestry waste. Background technique [0002] Dopamine (DA, or 3-hydroxytyramine, 3,4-dihydroxyphenylethylamine) is an endogenous nitrogen-containing organic compound, which is tyrosine (aromatic amino acid) in the metabolic process through dihydroxyphenylalanine produced intermediate products. Also known as catecholethylamine or hydroxytyramine, it is a kind of catecholamines with the molecular formula C 8 h 11 NO 2 . In addition to being the precursor of norepinephrine, dopamine is also an important neurotransmitter to maintain the function of extrapyramidal system. In addition, it is also an effective anti-shock and cardiotonic diuretic, which is widely used clinically. [0003] Agricultural and forestry waste is biomass waste produced in agricultural production...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/06C07C215/52C07C217/60B01J19/00B01J19/18
CPCC07C213/06C07D317/22B01J19/00B01J19/1862C07C215/52C07C217/60Y02E50/30
Inventor 杨若菡董煜国梁晓璇王子丰林雨竺邢昊姚天煜董琳陈祖鹏顾晓利
Owner NANJING FORESTRY UNIV
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