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Debridement and bacteriostasis pharmaceutical composition for wounds and preparation method of debridement and bacteriostasis pharmaceutical composition

A technology of composition and medicine, which is applied in the field of medicine, can solve the problems that it is not suitable for the daily health care of ordinary people, and the antibacterial effect of Auranthus clematis preparation has not been found, so as to increase the wound burden, promote self-healing, and prevent infection

Inactive Publication Date: 2022-02-01
山东康克尔医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, fresh clematis, dried clematis and clematis tea are mainly sold in the market; there are also a small number of clematis compound oral liquids and sprays used as hospital preparations for patients to treat diseases, but hospital preparations only It is used for the treatment of hospital patients, not suitable for the daily health care of ordinary people
After searching, it has not been found that a certain simple formula of clematis preparation has excellent antibacterial effect

Method used

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  • Debridement and bacteriostasis pharmaceutical composition for wounds and preparation method of debridement and bacteriostasis pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prescription: Bacillus subtilis fermentation product 75mL, clematis extract 2 mL, benzalkonium chloride 150mg, purified water 1423 mL.

[0024] Preparation:

[0025] Add 18 times the amount of purified water to the dried Clematis clematis, soak for 15 minutes, then heat and extract in a 60°C water bath for 30 minutes, extract twice in a row, combine the filtrates, and concentrate the clematis extract to 0.5 g / mL.

[0026] Dissolve 150 mg of benzalkonium chloride in 23 mL of purified water by ultrasonic vortexing, add it to 1400 mL of purified water with 75 mL of Bacillus subtilis fermentation product and 2 mL of clematis extract, mix well, and put it into a spray bottle , that is.

Embodiment 2

[0028] Prescription: 70 mL of fermentation product of Bacillus subtilis, 2.1 mL of Aureus aureus extract, 160 mg of benzalkonium chloride, and 1428 mL of purified water.

[0029] Preparation:

[0030] Add 18 times the amount of purified water to the dried clematis, soak for 20 minutes, then heat and extract in a 65°C water bath for 25 minutes, extract twice in a row, combine the filtrates, and concentrate the clematis extract to 0.5 g / mL.

[0031] Dissolve 160 mg of benzalkonium chloride in 28 mL of purified water by ultrasonic vortexing, add it, 70 mL of Bacillus subtilis fermentation product, and 2.1 mL of Aureus aureus extract to 1400 mL of purified water, mix evenly, and put it into a spray bottle, ready to serve.

Embodiment 3

[0033] Prescription: Bacillus subtilis fermentation product 80mL, clematis extract 2.2 mL, benzalkonium chloride 130mg, purified water 1418 mL.

[0034] Preparation:

[0035] Add 17 times the amount of purified water to the dried Auranthus clematis, soak for 20 minutes, then heat and extract in a water bath at 55°C for 40 minutes, extract twice in a row, combine the filtrates, and concentrate the clematis extract to 0.6 g / mL.

[0036] Dissolve 130 mg of benzalkonium chloride in 18 mL of purified water by ultrasonic vortexing, add it to 1400 mL of purified water with 80 mL of Bacillus subtilis fermentation product and 2.2 mL of clematis extract, mix well, and put it into a spray bottle , that is.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a debridement and bacteriostasis pharmaceutical composition for wounds and a preparation method of the debridement and bacteriostasis pharmaceutical composition. The active ingredient of the pharmaceutical composition comprises a shorthairy antenoron extracting solution, and can also comprise antibacterial peptide and a cationic surface active agent. The composition has an excellent antibacterial effect, can accelerate the growth of wound granulation and promote the healing of wound conjunctiva, is remarkable in curative effect, safe, reliable and free of toxic and side effects, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a wound debridement and antibacterial pharmaceutical composition and a preparation method thereof. Background technique [0002] Wounds are the breakdown of the function and integrity of tissues in the body, and wound healing is a complex process of repair that is affected by a variety of internal and external factors, including infection, steroid therapy, malnutrition, concomitant medical diseases such as diabetes, and Factors that reduce the local blood supply. Trauma infection is unavoidable. Although the commonly used western medicines have curative effects, they are irritating to the body and may produce drug resistance and side effects to a certain extent. Antimicrobial peptides are small molecule polypeptides with antibacterial activity induced in organisms (the relative molecular mass is usually below 1×104D), which are widely found in bacteria, fungi, amphi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K35/742A61K38/16A61K9/12A61K47/18A61P17/02A61P31/02A61P31/04A61P31/10
CPCA61K36/898A61K35/742A61K9/12A61K9/0014A61K47/186A61P17/02A61P31/04A61P31/02A61P31/10A61K38/164A61K2300/00
Inventor 董金呈
Owner 山东康克尔医疗器械有限公司
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