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Iron-based nano catalytic treatment reagent and preparation method and application thereof

A technology of nano-catalysis and therapeutic reagents, applied in chemical instruments and methods, physical/chemical process catalysts, nanotechnology, etc., can solve the problems of low reaction efficiency, achieve strong catalytic ability, induce cancer cell apoptosis, and improve hypoxia environmental effects

Pending Publication Date: 2022-01-28
JIANGSU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The Fenton reaction efficiency of the traditional nanocatalytic therapeutic agent is low, and it cannot cooperate with other therapeutic methods such as drug therapy, photodynamic therapy, photothermal therapy, and radiation therapy to carry out multimodal treatment to maximize the effect of cancer treatment

Method used

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  • Iron-based nano catalytic treatment reagent and preparation method and application thereof
  • Iron-based nano catalytic treatment reagent and preparation method and application thereof
  • Iron-based nano catalytic treatment reagent and preparation method and application thereof

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Effect test

Embodiment 1

[0047] The iron-based nanocatalytic therapeutic agent of the present invention includes nanoparticles, the nanoparticles are composed of Fe metal ions, 6-thioguanine and Meso-tetrakis(4-carboxyphenyl)porphine in a molar ratio of 2:1:1 The reaction is obtained.

[0048] The preparation method of the above-mentioned iron-based nano-catalyzed therapeutic agent comprises the following steps:

[0049] (1) Solution A: Weigh 0.016g of Pluronic F127 and 0.0107g of FeCl 3 With a round bottom flask, add 15 ml of DI water to dissolve by sonication. Connect the device to the constant temperature magnetic stirrer, and stir vigorously for 1 h at 25°C; then add 15 μl of glacial acetic acid solution to the flask, and stir for another 1 h.

[0050] (2) Solution B: Take 0.0261g TCPP and 0.0055g TG into a flask and dissolve in 5ml DI water.

[0051] (3) Hydrothermal reaction of mixed solution C: mixed solution A and solution B were mixed and stirred for 2 hours to obtain mixed solution C, the...

Embodiment 2

[0068] The iron-based nanocatalytic therapeutic agent of the present invention includes nanoparticles, the nanoparticles are composed of Fe metal ions, 6-thioguanine and Meso-tetrakis(4-carboxyphenyl) porphine in a molar ratio of 3:3:2 The reaction is obtained.

[0069] The preparation method of the above-mentioned iron-based nano-catalyzed therapeutic agent comprises the following steps:

[0070] (1) Solution A: Weigh 0.016g of trimethylolpropane and 0.0162g of FeCl 3 With a round bottom flask, add 15 ml of DI water to dissolve by sonication. Connect the device to the constant temperature magnetic stirrer, and stir vigorously for 1.5 h at 25°C; then add 15 μl of formic acid solution to the flask, and stir for another 1.5 h.

[0071] (2) Solution B: Take 0.0522g TCPP and 0.0165g TG into a flask and dissolve in 5ml DI water.

[0072] (3) Hydrothermal reaction of mixed solution C: mixed solution A and solution B were mixed and stirred for 3 hours to obtain mixed solution C. T...

Embodiment 3

[0074] The iron-based nanocatalytic therapeutic agent of the present invention includes nanoparticles, which are composed of Fe metal ions, 6-thioguanine and Meso-tetrakis(4-carboxyphenyl) porphine in a molar ratio of 2:1:1 The reaction is obtained.

[0075] The preparation method of the above-mentioned iron-based nano-catalyzed therapeutic agent comprises the following steps:

[0076] (1) Solution A: Weigh 0.016g of dipentaerythritol and 0.0107g of FeCl3 into a round-bottomed flask, add 15ml of DI water to dissolve by ultrasonic. Connect the device to the constant temperature magnetic stirrer, and stir vigorously at 25° C. for 10 min; then add 15 μl of propionic acid solution to the flask, and stir for another 20 min.

[0077] (2) Solution B: Take 0.0261g TCPP and 0.0055g TG into a flask and dissolve in 5ml DI water.

[0078] (3) Hydrothermal reaction of mixed solution C: mixed solution A and solution B were mixed and stirred for 1 hour to obtain mixed solution C, the solut...

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Abstract

The invention discloses an iron-based nano catalytic treatment reagent and a preparation method and application thereof, the iron-based nano catalytic treatment reagent comprises nanoparticles, and the nanoparticles are obtained by reaction of Fe metal ions, 6-thioguanine and Meso-tetra (4-carboxyphenyl) porphin according to a molar ratio of 2: 1: 1-3: 2: 2. The iron-based nano-catalytic treatment reagent prepared by a hydrothermal method is a nano-catalytic drug, shows relatively strong catalytic ability, and can catalyze hydrogen peroxide to generate oxygen and improve a hypoxic environment of tumors; meanwhile, the reagent has the properties of peroxidase mimicase and can be used for catalyzing the generation of highly oxidative hydroxyl radicals in cancer cells to induce apoptosis of the cancer cells, 6-thioguanine contained in the reagent can be used for tumor chemotherapy, and Meso-4-(4-carboxyphenyl) porphine can be used for tumor photodynamic therapy. the preparation method is simple and convenient, wide in raw material source, low in cost, repeatable and suitable for industrial production and application.

Description

technical field [0001] The invention relates to the field of chemical nanomaterials, in particular to an iron-based nanocatalytic therapeutic agent and a preparation method and application thereof. Background technique [0002] There is increasing evidence that tumor cells exhibit consistently higher levels of reactive oxygen species (ROS) than normal cells due to genetic, metabolic, and microenvironmental changes. Excessive ROS levels in tumor cells can induce cell death, senescence, and cell cycle arrest. At high ROS levels, oncogenes induce tumor cells to adapt to oxidative stress and upregulate antioxidant systems, resulting in increased ROS scavenging rates to maintain ROS levels, allowing activation of cancer-promoting signals without inducing cell death. Therefore, the "Vulnerable redox homeostasis" maintained by high levels of ROS and high levels of antioxidant systems provides a new idea for the treatment of tumors. [0003] Ferroptotic therapy (Ferroptotic Therap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/02B01J31/18C09K11/06A61K41/00A61P35/00B82Y5/00B82Y40/00
CPCC07F15/025B01J31/1835C09K11/06A61K41/0071A61P35/00B82Y5/00B82Y40/00C09K2211/187B01J35/23
Inventor 郑芬芬孙嘉敏刘文静吕海敏潘一璠蒋恺
Owner JIANGSU UNIV OF SCI & TECH
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