Interstitial fluid detection device and system thereof

Abstract

The invention discloses an interstitial fluid detection device and a system thereof. The interstitial fluid detection device comprises a microneedle array, an elastic layer, an electrode array, a pressurizing unit and a control circuit; the microneedle array comprises a substrate and a needle body and is used for penetrating through a skin cuticle to form a tissue fluid exudation channel; the elastic layer covers the substrate, is in contact with the needle body and is used for providing vertical elastic force; the electrode array comprises a flexible substrate modified with a plurality of layers of patterned functional materials, the electrode array covers the elastic layer, and circular holes arranged correspondingly to the microneedle array are formed in the flexible substrate of the electrode array; the pressurizing unit is used for providing pressure so that the needle body part can penetrate through the skin cuticle; and the control unit is used for controlling the pressure of the pressurizing unit and transmitting a tissue fluid biochemical index signal detected by the electrode array. The embodiment of the invention can noninvasively, accurately and continuously monitor a plurality of indexes of the tissue fluid, and can be widely applied to the technical field of medical instruments.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an interstitial fluid detection device and a system thereof. Background technique [0002] Diabetes is a major chronic disease. Although diabetes has a relatively single detection index, that is, blood sugar concentration, many patients may have multiple diseases and require frequent detection of various indicators in the body. For example, the common complications of diabetes include ketoacidosis, which is prominently manifested as electrolyte imbalance. Some severe patients can cause severe hyponatremia and hypokalemia, which is life-threatening. However, if real-time blood sugar, blood sodium, and blood potassium tests are performed on diabetic patients, blood sugar concentration can be effectively controlled, electrolytes can be replenished in time, and osmotic pressure can be maintained in the body. Combined with good living habits, the risk of diabetic complications...

AI Technical Summary

Problems solved by technology

[0003] At present, blood sugar, blood sodium and blood potassium are often used clinically to draw venous blood for measurement, which requires patients to take venous blood. This frequent invasive test brings great inconvenience and trauma to patients, and can only Reflecting test results at a small number of time points, continuous blood glucose, sodium and potassium tracking cannot be obtained

Implantable blood glucose monitoring systems rely on blood glucose sensing electrodes implanted under the skin. Although continuous monitoring of blood glucose fluctuations has been achieved, continuous monitoring of potassium ions and sodium ions has not yet been achieved; at the same time, this technology is easy to induce inflammation and rejection. In turn, it will greatly affect the accuracy of the electrodes in monitoring blood sugar, and it will also easily cause resistance and fear in patients.

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