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Application of dapagliflozin and analogue thereof in preparation of medicine for preventing and treating male reproductive dysfunction

A technology for male reproduction and dysfunction, applied in the field of biomedicine, to achieve high application value and social benefits

Active Publication Date: 2022-01-07
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of this class of drugs on reproductive function has not yet been reported

Method used

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  • Application of dapagliflozin and analogue thereof in preparation of medicine for preventing and treating male reproductive dysfunction
  • Application of dapagliflozin and analogue thereof in preparation of medicine for preventing and treating male reproductive dysfunction
  • Application of dapagliflozin and analogue thereof in preparation of medicine for preventing and treating male reproductive dysfunction

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Embodiment

[0036] 1. Experimental method:

[0037] Classic type 2 diabetic mice: leptin receptor double knockout mice (db / db mice, purchased from Jiangsu Jicui Yaokang Biotechnology Co., Ltd.), 8-week-old mice were selected, and after 1 week of adaptive feeding, The mice whose random blood glucose was detected to be ≥16.7mmol / L were included in this experiment. The mice were randomly divided into two groups: the diabetes group and the intervention group. Dapagliflozin (Dapa, 1 mg / kg body weight / day) and water (the same volume) were given respectively, orally administered once a day for 5 weeks. Littermate wild-type mice were also selected as normal controls. 9-10 in each group. Determination of fasting body weight, random body weight, fasting blood glucose and random blood glucose of mice before and after intervention

[0038] Typical features of leptin receptor-deficient model mice (db / db) include metabolic disturbances such as hyperleptinemia, obesity, hyperglycemia, hyperinsulinemi...

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Abstract

The invention belongs to the technical field of biological medicine. The invention particularly relates to application of an SGLT2 inhibitor in preparation of a medicine for preventing and treating male reproductive dysfunction. Research results show that dapagliflozin treatment can increase testis weight and testis / body weight ratio of db / db mice, and can significantly improve sperm quality abnormality, sperm quantity abnormality and sperm movement abnormality of the db / db mice. According to the application, the SGLT2 inhibitor is used for preventing or treating male reproductive dysfunction for the first time, an ideal treatment effect is achieved, a new prevention and treatment choice is provided for treating male sterility in clinical application, especially male sterility caused by diabetes or hyperglycemia, and the application has extremely high application value and social benefits.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. It specifically relates to the use of SGLT2 inhibitors (especially dapagliflozin and its analogues) in the preparation of drugs for preventing and treating male reproductive dysfunction. Background technique [0002] In recent years, with the aggravation of environmental pollution and the delay of childbearing age, the incidence of male infertility has been increasing year by year. The most direct consequence of the increase in the incidence of infertility is the reduction of the fertility rate, which will further accelerate the process of my country's entry into an aging society. Sustainable development poses serious challenges. The occurrence of infertility is related to many factors, the individual differences are large, and the pathogenic factors are complex, which brings difficulties to the research and treatment of the disease. The incidence of male infertility is related to many fact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/351A61K31/7048A61K31/382A61K31/35A61K31/381A61P15/08
CPCA61K45/00A61K31/351A61K31/7048A61K31/382A61K31/35A61K31/381A61P15/08
Inventor 魏蕊金滋润张哲杨进魏天娇洪天配姜辉杨宇卓
Owner PEKING UNIV THIRD HOSPITAL
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