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Traditional Chinese medicine extract for treating hyperhomocysteinemia and preventing myocardial infarction and cerebral infarction

A cysteinemia, traditional Chinese medicine technology, applied in the directions of drug delivery, drug combination, blood diseases, etc., can solve problems such as slow onset of action, achieve a simple and convenient preparation method, and reduce the effect of preventing and treating cardiovascular and cerebrovascular diseases.

Pending Publication Date: 2022-01-07
任秀江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the clinical drugs for the prevention and treatment of hyperhomocysteinemia mainly intervene in the transmethylation pathway or transsulfurization pathway of homocysteine, or the compound preparations containing B vitamins and folic acid that intervene in both pathways at the same time. , but currently clinically used drugs are slow in their onset of action

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of a traditional Chinese medicine composition for treating hyperhomocysteinemia is:

[0027] S1. Extraction liquid: mix 20 kg of astragalus, 20 kg of angelica, 20 kg of gardenia, and 240 liters of water and heat to 90°C for 90 minutes to obtain water extract A1; mix 20 kg of Anhua black tea with 200 liters of water Heat to 90°C and extract for 60 minutes to obtain water extract B1.

[0028] S2. Filtration: filter the water extracts A1 and B1 obtained in step S1 through a filter membrane to obtain fine water extract filtrates A2 and B2;

[0029] S3. Oxidation: Heat the fine water extraction fine filtrate A2 obtained in step S2 to 80° C., and then fill it with edible oxygen, the total amount is 0.05 cubic meters under one atmospheric pressure, and the oxygenation time is 100 minutes; the oxidation solution A3 is obtained.

[0030] S4. Mixing: Mix B2 obtained in step S2 and A3 obtained in step S3 evenly to obtain a mixed liquid AB.

[0031] S5, bottl...

Embodiment 2

[0056] A preparation method of a traditional Chinese medicine composition for treating hyperhomocysteinemia is:

[0057] S1. Extraction liquid: mix 30 kg of astragalus, 15 kg of angelica, 15 kg of gardenia, and 240 liters of water and heat to 90°C for 90 minutes to obtain water extract A1; mix 18 kg of Anhua black tea with 180 liters of water Heat to 90°C and extract for 60 minutes to obtain water extract B1.

[0058] S2. Filtration: filter the water extracts A1 and B1 obtained in step S1 through a filter membrane to obtain fine water extract filtrates A2 and B2;

[0059] S3. Oxidation: Heat the fine water extraction fine filtrate A2 obtained in step S2 to 80° C., and then fill it with edible oxygen, the total amount is 0.05 cubic meters under one atmospheric pressure, and the oxygenation time is 100 minutes; the oxidation solution A3 is obtained.

[0060] S4. Mixing: Mix B2 obtained in step S2 and A3 obtained in step S3 evenly to obtain a mixed liquid AB.

[0061] S5, bottl...

Embodiment 3

[0063] A preparation method of a traditional Chinese medicine composition for treating hyperhomocysteinemia is:

[0064] S1. Extraction liquid: mix 25 kg of astragalus, 18 kg of angelica, 17 kg of gardenia, and 240 liters of water and heat to 90°C for 90 minutes of constant temperature extraction to obtain water extract A1; 25 kg of Anhua dark tea, mixed with 250 liters of water Heat to 90°C and extract for 60 minutes to obtain water extract B1.

[0065] S2. Filtration: filter the water extracts A1 and B1 obtained in step S1 through a filter membrane to obtain fine water extract filtrates A2 and B2;

[0066] S3. Oxidation: Heat the fine water extraction fine filtrate A2 obtained in step S2 to 80° C., and then fill it with edible oxygen, the total amount is 0.05 cubic meters under one atmospheric pressure, and the oxygenation time is 100 minutes; the oxidation solution A3 is obtained.

[0067] S4. Mixing: Mix B2 obtained in step S2 and A3 obtained in step S3 evenly to obtain a...

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Abstract

The invention discloses a traditional Chinese medicine extract for treating hyperhomocysteinemia and preventing myocardial infarction and cerebral infarction, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 20 to 30 parts of radix astragali seu hedysari, 15 to 20 parts of Chinese angelica root, 8 to 20 parts of fructus gardeniae and 18 to 25 parts of Anhua dark tea. A preparation method of the traditional Chinese medicine composition comprises the following steps of: (1) extracting immersion liquid: mixing the radix astragali seu hedysari, the Chinese angelica root, the fructus gardeniae and water, heating and extracting at constant temperature to obtain a water extracting solution A1; mixing the Anhua dark tea and a certain amount of water, heating and extracting to obtain a water extracting solution B1; (2) filtering: filtering the water extracting solutions A1 and B1 obtained in the step S1 through a filtering membrane to obtain water extracting fine filtrate A2 and B2; (3) oxidizing: heating the water extracting fine filtrate A2 obtained in the step S2 and introducing oxygen to obtain an oxidized solution A3; (4) mixing: uniformly mixing the B2 obtained in the step S2 and the A3 obtained in the step S3 to obtain a mixed solution AB; and (5) bottling and sterilizing.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine extract for treating hyperhomocysteinemia and preventing myocardial infarction and cerebral infarction. Background technique [0002] Homocysteine ​​(Hcy) is a sulfur-containing amino acid and an important intermediate product in the metabolism of methionine. At present, it is believed that hyperHcyemia is a sensitive indicator of folic acid and vitamin B12 deficiency in the body, and an independent risk factor for cardiovascular and cerebrovascular diseases such as coronary heart disease and atherosclerosis. Thrombosis, cardiovascular toxicity, etc. The clinical manifestations of some kidney diseases, liver diseases, metabolic diseases, nervous system diseases, cancer, and certain drug intakes are abnormally elevated homocysteine ​​in the blood. Among patients with atherosclerosis, the prevalence of hyper-Hcyemia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/08A61P3/00A61P7/00
CPCA61K36/481A61K36/232A61K36/744A61K36/82A61K9/0095A61P3/00A61P7/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 任秀江任璐任旭红任妍熹
Owner 任秀江
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