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A kind of wound surface liquid dressing and preparation method thereof

A wound surface liquid and system technology, which is applied to the preparation of several thousand words of wound liquid dressing, liquid dressing and its preparation field, can solve the problems of unclear active ingredients, the inability of Band-Aid film to meet the waterproofness and breathability at the same time, and the complex formula, etc. Good breathability, anti-inflammatory and healing effect, simple formula effect

Active Publication Date: 2022-07-29
WUFENG CHICHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the technical defects of existing liquid band-aids such as complicated formula, unclear active ingredients, mostly synthetic or semi-synthetic chemicals in film-forming substrates, and formation of band-aid films that cannot simultaneously satisfy good water resistance and air permeability. A wound liquid dressing and a preparation method thereof are provided. The wound liquid dressing of the present invention quickly forms a film on the skin surface, and has good bacteria resistance, air permeability and liquid absorption, and has good anti-inflammatory and healing effects on wounds. The healing speed is fast, the healing rate is high, it meets the relevant requirements of the national standard, meets the needs of wound liquid dressings in daily life and medical treatment, and has a good application prospect

Method used

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  • A kind of wound surface liquid dressing and preparation method thereof
  • A kind of wound surface liquid dressing and preparation method thereof
  • A kind of wound surface liquid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0067] Example 1A Synthesis of compound GA-C 28

[0068] 1. Accurately weigh gallic acid monohydrate (2.26 g, 12.0 mmol) and n-octacosanol (1.65 g, 4.0 mmol), and add them to a two-necked bottle with a water separator and a thermometer. The molar ratio of octacosanol is 3:1;

[0069] In the embodiment of the present invention, the molar ratio of gallic acid to n-octacosanol is taken as 3:1 as an example, and other moles such as (2-4.5):1 are also applicable to the present invention.

[0070] 2. Accurately measure 20.0mL (usually 15.0-35.0mL) of 1,4-dioxane solvent and add it to a two-necked bottle;

[0071] Usually the ratio of solvent dosage to octacosanol is 9-22:1, that is, the liquid-solid ratio of solvent to octacosanol is 9-22:1, that is, the volume of solvent and the mass of octacosanol The ratio is 9-22:1, and each 1g of octadecanol is dissolved with 9-22ml solvent; the liquid-solid ratio of solvent dosage and gallic acid is 6.6-15.5:1, that is, the liquid-solid rat...

Embodiment 1

[0084] Weigh a certain quality of bleached shellac, plasticizer PEG1k, GA-C 28 ; Bleached shellac, PEG1K, GA-C under stirring 28 Add to 15.0mL of absolute ethanol, stir and heat the mixture to 45°C (usually 35-50°C), keep the temperature at 45°C, stir and mix for 2.5h (usually 2-4h); then add 5.0mL The ethyl acetate can dissolve the solid completely; after the mixed solution is naturally cooled to room temperature, the wound surface liquid dressing of the present invention is obtained;

[0085] In this example, the amount of plasticizer PEG1k added is 0.40g, GA-C 28 The addition amount of 0.03g, and the addition amount of bleached shellac were 1.00, 1.40, 1.80, 2.20, 2.60g, respectively, to prepare 5 wound liquid dressing samples (named as samples 1-5), and each treatment was repeated 3 times.

[0086] Use NDJ-8S rotational viscometer (Shanghai Jingke Industrial Co., Ltd.) to measure the viscosity of the wound liquid dressing prepared in Example 1: respectively accurately me...

Embodiment 2

[0090] Weigh a certain quality of bleached shellac, plasticizer PEG1k, GA-C 28 ; Bleached shellac, PEG1K, GA-C under stirring 28 Add to 15.0mL of absolute ethanol, stir and heat the mixture to 45°C (usually 35-50°C), keep the temperature at 45°C, stir and mix for 2.5h (usually 2-4h); then add 5.0mL The ethyl acetate can dissolve the solid completely; after the mixed solution is naturally cooled to room temperature, the wound surface liquid dressing of the present invention is obtained;

[0091] In the present embodiment, the added amount of controlling bleached shellac is 1.80g, GA-C 28 The addition amount of 0.03g and the addition amount of plasticizer were 0.40g. The plasticizers were PEG1k, PEG2k, PEG4k, PEG10k, PVA, and PVP, respectively, to prepare 6 liquid dressing samples, and each treatment was repeated 3 times. The sample without plasticizer was set as the blank control.

[0092] Accurately measure 5.0 mL of each of the six liquid dressings prepared in Example 2, s...

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Abstract

The invention discloses a wound surface liquid dressing liquid and a preparation method thereof. The liquid dressing comprises bleached shellac, plasticizer, stearyl gallate (GA-C 28 ) and solvent system, the liquid dressing of the present invention is GA-C 28 As the active ingredient, the spray-type GA-C is prepared with natural, non-toxic and degradable bleached shellac as the film-forming substrate. 28 / Bleached shellac wound liquid dressing, which quickly forms a film on the skin surface, and the film has good air permeability and liquid absorption, and has a certain anti-deformation ability. The healing rate is high, meets the relevant requirements of the national standard, meets the needs of daily life and medical treatment for wound liquid dressings, and has good application prospects. The preparation method of the liquid dressing of the present invention has simple operation and mild process conditions, and is suitable for industrialized large-scale production.

Description

technical field [0001] The invention relates to a liquid dressing and a preparation method thereof, in particular to a preparation method of a wound surface liquid dressing of several thousand characters, belonging to the technical field of medicine preparation. Background technique [0002] Superficial skin injuries such as minor scratches, cuts, contusions and burns are extremely common in daily life, and the use of Band-Aids is the most commonly used care method. Liquid wound dressing is a new type of Band-Aid that can be used to disinfect wounds, promote wound healing, and replace ordinary Band-Aids when cuts, abrasions, cracks, chapped and other wounds appear. It belongs to biofilm-forming disinfectants. The wound liquid dressing is applied by spraying or smearing to form a protective film on the wound, which combines the continuous disinfection function and the protection function of the wound into one, and has good sterilization. Compared with traditional liquid band...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/00A61L26/0019A61L26/0057A61L26/0061A61L2300/412A61L2300/41A61L2300/404A61L2300/216C08L71/02
Inventor 刘兰香张弘陈赤清毛业富刘义稳战祥宁然谢山宇
Owner WUFENG CHICHENG BIOTECH
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