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Application in guiding hypertension treatment scheme

A treatment plan and application technology, applied in the field of medicine, can solve problems such as differences in long-term curative effect, patients' different responsiveness to drug treatment, and impact

Pending Publication Date: 2021-12-17
深圳市长卿医学研究院 +1
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Problems solved by technology

[0004] However, in the real world (real medical environment), due to various differences among individuals with hypertension, such as genetic or family history background, age and sex, weight, basic state or other combined pathological conditions, each patient is Responsiveness to drug therapy varies, including differences in long-term outcomes
Therefore, for hypertensive patients, not only the index of blood pressure control (below 140 / 90mmHg) affects their prognosis, but there may be other factors, but we know little about it

Method used

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  • Application in guiding hypertension treatment scheme
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Examples

Experimental program
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Embodiment 1

[0024] Example 1 Study on the blood calcium concentration of CSPPT male patients and the risk of stroke after different antihypertensive treatments (1) method:

[0025] 1. China Primary Stroke Prevention Study (CSPPT):

[0026] CSPPT is a randomized double-blind controlled trial conducted in Anhui and Jiangsu provinces, China from 2008 to 2013. A total of 20,702 male and female hypertensive patients, aged 45-75 years, were included. Hypertension was defined as sitting systolic blood pressure ≥ 140mmHg And / or diastolic blood pressure ≥90mmHg. Patients were randomly assigned to one of two treatment groups at a ratio of 1:1: "Yiye group" patients took orally 1 tablet of compound enalapril folic acid tablet (containing 10 mg enalapril and 0.8 mg folic acid) per day, "Yiye group" Patients in the Puli group” took 1 tablet of 10 mg enalapril orally every day, and each patient took the medicine for not less than 4 years; the patients were followed up every 3 months to record blood pr...

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Abstract

The invention provides application of detecting blood calcium concentration to guide a tested individual (male hypertensive patient) to accept an antihypertensive treatment scheme. The application is beneficial to reducing the occurrence risk of cerebral apoplexy of the tested individual. The invention further relates to a detection system for guiding the tested individual to receive a treatment regimen. Through data analysis of clinical intervention research on hypertension people, the invention finds that when the baseline blood calcium concentration of the tested individual is higher than a certain threshold value, combined treatment of an angiotensin converting enzyme inhibitor hypotensive drug and folic acid substances on the individual is more beneficial to reduction of the occurrence risk of cerebral apoplexy than pure hypotensive treatment. Therefore, the application can be used for guiding individualized medical treatment, namely making or selecting a specific medical intervention scheme for an individual.

Description

technical field [0001] The invention relates to an application of detecting blood calcium concentration, which is used to guide a subject (male hypertensive patient) to accept an antihypertensive treatment plan to reduce the risk of cerebral apoplexy, and belongs to the field of medicine. Background technique [0002] Stroke is the second leading cause of death worldwide, second only to ischemic heart disease. In my country, the death rate caused by cerebrovascular disease has surpassed that of cancer, ranking first among the causes of death among residents. Therefore, the prevention and control of cerebrovascular diseases is of great significance. Hypertension is the primary risk factor for stroke. Compared with people with normal blood pressure, the risk of stroke in hypertensive patients increases by 3 to 4 times. There is a strong causal relationship between blood pressure levels and the risk of cerebrovascular disease morbidity and mortality. A meta-analysis of prosp...

Claims

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Application Information

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IPC IPC(8): G01N33/84
CPCG01N33/84G01N2800/321
Inventor 徐希平王滨燕秦献辉李幼宝
Owner 深圳市长卿医学研究院
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