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Application of diethyl n-butylmalonate in preparation of medicines for preventing and treating obesity

A technology of diethyl n-butylmalonate and drugs, applied in the field of biomedicine, to achieve the effects of improving obesity-related metabolic disorders, increasing body fatty acid oxidation and energy consumption, and preventing lipid accumulation in liver tissue

Pending Publication Date: 2021-12-17
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether it can prevent and treat obesity has not been reported

Method used

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  • Application of diethyl n-butylmalonate in preparation of medicines for preventing and treating obesity
  • Application of diethyl n-butylmalonate in preparation of medicines for preventing and treating obesity
  • Application of diethyl n-butylmalonate in preparation of medicines for preventing and treating obesity

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the embodiments and accompanying drawings.

[0025] The invention provides the application of n-butylmalonate diethyl in preparing anti-obesity drugs.

[0026] In the present invention, the n-butylmalonate diethyl can reduce the body weight and liver weight of mice, reduce liver tissue accumulation, promote fatty acid oxidation and energy consumption in mice, and prevent obesity. In the present invention, the n-butyl malonate diethyl can prevent the accumulation of liver tissue lipids, can improve glucose tolerance and insulin resistance, and has the effect of correcting obesity-related metabolic disorders.

[0027] In the present invention, the n-butyl malonate diethyl is prepared into a medicine for preventing and treating obesity. In the medicine for preventing and treating obesity, the diethyl n-butylmalonate is administered at 25 mg / kg body weight, and the administration method is preferably ...

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Abstract

The invention provides an application of diethyl n-butylmalonate in preparation of medicines for preventing and treating obesity, and belongs to the technical field of biomedicines. Diethyl n-butylmalonate can reduce body weight and liver weight in obese mice, prevent lipid accumulation in liver tissues, enhance fatty acid oxidation in obese mice and increase energy consumption so as to achieve weight losing effect. Moreover, Diethyl n-butylmalonate can improve glucose tolerance and insulin resistance, and has the effect of correcting obesity-related metabolic disorders.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of n-butylmalonate diethyl in preparing anti-obesity drugs. Background technique [0002] Obesity is an epidemic and systemic metabolic disease that seriously endangers human health. Obesity is a metabolic syndrome caused by abnormal energy metabolism, excessive accumulation and abnormal distribution of body fat caused by genetics, lifestyle, immune status and other factors. It is closely related to insulin resistance, diabetes, hyperlipidemia, hypertension, fatty liver, cardiovascular disease and cognitive impairment. At present, most weight loss methods have the disadvantages of large side effects and high recurrence rate, especially a large number of weight loss drugs have been withdrawn from the market due to safety issues. In view of the increasingly serious obesity and the increasing incidence of metabolic diseases caused by obesity year by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/225A61P3/04A61P3/10A61P5/50
CPCA61K31/225A61P3/04A61P3/10A61P5/50
Inventor 于英华潘伟赵进秀蒋鹏飞徐大祥杨晓莹张鹏胡敏敏胡涛李梦迪
Owner XUZHOU MEDICAL UNIV
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