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Pharmaceutical assembly containing formoterol fumarate inhalation solution and application of pharmaceutical assembly

A technology of formoterol fumarate and solution, applied in the medical field, can solve the problems of wide droplet particle size distribution, large volume, inconvenience, prolonged treatment time, etc., achieves good clinical treatment of chronic obstructive pulmonary disease, is easy to carry and use handy effect

Active Publication Date: 2021-12-10
JIANKANGYUAN PHARMA GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the nebulizer is used for drug administration, the droplet size distribution is wide, the geometric standard deviation range is large, the volume is large, it is inconvenient to carry, the noise is large, the energy consumption is high, the residual liquid volume is large, and the treatment time is prolonged. , compliance reduction and other defects

Method used

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  • Pharmaceutical assembly containing formoterol fumarate inhalation solution and application of pharmaceutical assembly
  • Pharmaceutical assembly containing formoterol fumarate inhalation solution and application of pharmaceutical assembly
  • Pharmaceutical assembly containing formoterol fumarate inhalation solution and application of pharmaceutical assembly

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Metal meshes with different numbers of perforations but the same micropore diameter were selected and applied to the same vibrating mesh nebulizer, and their effects on the nebulization effect when applied to formoterol inhalation solution were tested. The results are shown in Table 1.

[0055]

Embodiment 2

[0057] Metal mesh sheets with different pore diameters but the same number of perforations were selected and applied to the vibrating mesh nebulizer with the same vibration frequency, and their influence on the nebulization effect of the formoterol inhalation solution was tested. The results are shown in Table 2.

[0058]

Embodiment 3

[0060] Investigate the same type of vibrating screen nebulizer with the same parameters of the metal mesh, when the ratio of the number of micropores with a pore size of 3.2-4.0 μm to the total number of micropores is different, the application of the atomization effect of formoterol inhalation solution The results can be seen in Table 3.

[0061]

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Abstract

The invention relates to a pharmaceutical assembly containing a formoterol fumarate inhalation solution and an application of the pharmaceutical assembly. The pharmaceutical assembly comprises: (a) the formoterol fumarate inhalation solution; and (b) a vibrating screen atomizer used in cooperation with the formoterol fumarate inhalation solution, wherein the atomization power of the vibrating screen atomizer is decreased from 10 watts to 0 watt in a stepped decreasing mode, and the fogdrop particle sizes of the formoterol fumarate inhalation solution are as follows: D<10> is 0.5-1.5 [mu]m, D<50> is 2.5-4.5 [mu]m, and D<90> is 6.0-12.0 [mu]m. The mass percentage of the particles with the aerodynamic particle size smaller than 5.39 [mu]m in the formoterol fumarate inhalation solution is not smaller than 30%. According to the pharmaceutical assembly, the good effect of clinically treating the chronic obstructive pulmonary disease is achieved, and besides, the used vibrating screen atomizer has the advantages of being small in residual medicine liquid size, convenient to use and carry and low in noise.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a pharmaceutical component containing formoterol fumarate inhalation solution and its application. Background technique [0002] Chronic obstructive pulmonary disease (COPD, referred to as COPD) is a common and frequently-occurring disease that seriously endangers human health, seriously affects the quality of life of patients, has a high mortality rate, and brings heavy economic costs to patients and their families. burden. The aerosol inhalation treatment of COPD is difficult to conduct clinical trials due to its special patient population, special administration methods or devices. Studies have shown that the randomized control population eligible for COPD accounted for only 7.2% of the total screened population; and the correct use of inhalation devices and operating methods is crucial to exerting the curative effect. [0003] Formoterol is N-acylanilide derived from epine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61K9/72A61P11/00A61M11/00
CPCA61K31/167A61K9/08A61K9/12A61K9/0078A61P11/00A61M11/001A61M11/006
Inventor 金方郦旻邓炜连晓培黄娟俞雄
Owner JIANKANGYUAN PHARMA GROUP
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