Plant bacteriostatic skin-care nano-emulsion and preparation method thereof

A nanoemulsion, plant-based technology, applied in the field of biomedicine, can solve the problems of needing to be improved, low bioavailability, poor solubility, etc., to improve bioavailability and water solubility, simple preparation process, and good stability Effect

Active Publication Date: 2021-12-07
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of botanical medicines that are convenient for skin infections needs to be improved
On the one hand, there is no particularly outstanding effect in terms of formula. On the other hand, because many plant extracts have poor solubility in water, it is difficult to be absorbed by the human body, and there is a problem of extremely low bioavailability.

Method used

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  • Plant bacteriostatic skin-care nano-emulsion and preparation method thereof
  • Plant bacteriostatic skin-care nano-emulsion and preparation method thereof
  • Plant bacteriostatic skin-care nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A plant antibacterial skin care nanoemulsion, prepared from plant antibacterial components, emulsifiers and water, wherein the plant antibacterial components and their weight percentages in the nanoemulsion are respectively: Lemongrass oil 1%, citrus essential oil 1%, lavender essential oil 1%, peppermint essential oil 1%, licorice extract 0.5%, polylysine 0.5%, berberine 0.5%, matrine 0.5%, tanshinone 0.5 %. The lemongrass oil, citrus essential oil, lavender essential oil, and peppermint essential oil used were all purchased from Beijing Huajuan Aroma Technology Co., Ltd., polylysine (molecular weight less than 5000) and tanshinone were purchased from Shanghai Macklin Biochemical Technology Co., Ltd. Alkaline and matrine were purchased from Shaanxi Bowei Biotechnology Co., Ltd., and licorice extract was obtained by soaking licorice in absolute ethanol for 20 hours. The preparation method is:

[0024] S1, heating and dissolving the emulsifier Tween 80, polyglycerol 10...

Embodiment 2

[0034] A plant antibacterial skin care nanoemulsion, prepared from plant antibacterial components, emulsifiers and water, wherein the plant antibacterial components and their weight percentages in the nanoemulsion are respectively: Lemongrass Oil 1.5%, Citrus Essential Oil 1.5%, Lavender Essential Oil 1.5%, Peppermint Essential Oil 1.5%, Licorice Extract 0.5%, Polylysine 1%, Berberine 1%, Matrine 1%, Tanshinone 1 %. The preparation method is:

[0035] S1, heating and dissolving the emulsifier Tween 80, polyglycerol 10-myristate, and polyglycerol 10-monolaurate to form an emulsion;

[0036] S2, adding lemongrass essential oil, citrus essential oil, lavender essential oil, peppermint essential oil, licorice extract, and tanshinone into the emulsifier solution as an oil phase;

[0037] S3, dissolving matrine, polylysine, and berberine in deionized water as the water phase;

[0038] S4, adding the water phase to the oil phase and forming a coarse emulsion under a high-speed she...

Embodiment 3

[0045] A plant antibacterial skin care nanoemulsion, prepared from plant antibacterial components, emulsifiers and water, wherein the plant antibacterial components and their weight percentages in the nanoemulsion are respectively: Lemongrass oil 2%, citrus essential oil 1%, lavender essential oil 1%, peppermint essential oil 1%, licorice extract 0.5%, polylysine 0.5%, berberine 0.5%, matrine 0.5%, tanshinone 0.5 %. The preparation method is:

[0046]S1, heating and dissolving the emulsifier Tween 80, polyglycerol 10-myristate, and polyglycerol 10-monolaurate to form an emulsion;

[0047] S2, adding lemongrass essential oil, citrus essential oil, lavender essential oil, peppermint essential oil, licorice extract, and tanshinone into the emulsifier solution as an oil phase;

[0048] S3, dissolving matrine, polylysine, and berberine in deionized water as the water phase;

[0049] S4, adding the water phase to the oil phase and forming a coarse emulsion under a high-speed shea...

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Abstract

The invention discloses a plant bacteriostatic skin-care nano-emulsion and a preparation method thereof. The plant bacteriostatic skin-care nano-emulsion is prepared from a plant bacteriostatic component, an emulsifier and water, wherein the plant bacteriostatic component comprises the following components in percentage by weight in the nano-emulsion: 1%-2% of lemon citronella oil, 1%-2% of citrus essential oil, 1%-1.5% of lavender essential oil, 1%-1.5% of mint essential oil, 0.5% of a liquorice root extract, 0.5%-1% of polylysine, 0.5%-1% of berberine, 0.5%-1% of matrine and 0.5%-1% of tanshinone. The preparation method of the nano-emulsion comprises the following steps: heating the emulsifier for dissolving to form an emulsion; adding a fat-soluble component in the bacteriostatic component into the emulsion to serve as an oil phase; dissolving a water-soluble component in the bacteriostatic component into deionized water to serve as a water phase; and adding the water phase into the oil phase, forming a coarse emulsion under a high-speed shearing machine, and performing homogenizing at high pressure to obtain the plant bacteriostatic skin-care nano-emulsion.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a compounding of various plant functional factors and a preparation method of an embedding carrier, in particular to a plant antibacterial skin care nanoemulsion and a preparation method thereof. Background technique [0002] As the body's first line of defense, the skin is always resisting various bacterial and fungal infections from the outside world. Under normal circumstances, antibiotics can be used to control skin infections in the treatment of skin infections: (1) Mupirocin: For skin infections caused by Staphylococcus, Streptococcus, Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, etc. (2) Fusidic acid: mainly used for antibacterial treatment of streptococcus, enterococcus, diphtheria bacillus, clostridium, Neisseria, etc., for pneumonia, Osteomyelitis, sepsis and other serious diseases have a certain relieving effect; (3) Quinolones: This type of anti...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/92A61K8/88A61K8/49A61K8/06A61Q19/00A61Q17/00
CPCA61K8/9789A61K8/922A61K8/88A61K8/49A61K8/4973A61K8/4926A61K8/068A61K8/062A61Q19/00A61Q17/005A61K2800/413A61K2800/5922A61K2800/262A61K2800/805Y02A50/30
Inventor 梁浩康志伟周延
Owner BEIJING UNIV OF CHEM TECH
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