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Suture line with gel coating and preparation method thereof

A suture and gel technology, applied in coatings, medical science, surgery, etc., can solve problems such as rough surface of sutures, weak combination of coatings and sutures, etc., to promote healing, facilitate drug loading, and reduce friction pulling effect

Active Publication Date: 2021-12-03
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above-mentioned technical problems, the present invention provides a suture with a gel coating, which forms a layer of melting layer on the surface of the suture, and then forms a hydrogel coating through chemical cross-linking, which overcomes the problem of coating and suture. The problem of weak bonding and rough suture surface can greatly reduce the friction and pull with the tissue during and after the suture process, and achieve a strong combination of the coating and the suture, avoiding gel peeling during clinical application and recovery period

Method used

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  • Suture line with gel coating and preparation method thereof
  • Suture line with gel coating and preparation method thereof
  • Suture line with gel coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1 Silk suture surface melting layer formation

[0052] S1. A 16-spindle knitting machine is used, the knitting parameters are gear ratio 81 / 44#, knitting speed 80rmp, the thread body part of the suture thread is made of two strands of raw silk, 2.2Tex silk is used as the shell thread, and 7.3Tex is used. The silk is used as the core wire. According to the requirements of 2-0 in the YY0167-2020 standard, a braided medical suture was designed with a diameter of 0.300-0.349mm.

[0053] S2. Measure the braided silk suture, dip in the mixed solution of lithium bromide solution and BDDE, and prepare a hydrogel on its surface after partially dissolving. Orthogonal tests were carried out on LiBr concentration, reaction temperature and reaction time conditions:

[0054] Lithium bromide concentration: 1M, 2M, 3M, 4M, 5M, 6M, 7M, 8M, 9.3M, 9.5M, 9.8M.

[0055] Reaction time: 1 minute, 3 minutes, 5 minutes, 7 minutes, 10 minutes, 20 minutes, 30 minutes, 40 minutes.

...

Embodiment 2

[0069] Embodiment 2 Utilizes the melt layer to directly form a hydrogel coating on the surface of the silk suture

[0070] S1. A 16-spindle knitting machine is used, the knitting parameters are gear ratio 81 / 44#, knitting speed 80rmp, the thread body part of the suture thread is made of two strands of raw silk, 2.2Tex silk is used as the shell thread, and 7.3Tex is used. The silk is used as the core wire. According to the requirements of 2-0 in the YY0167-2020 standard, a braided medical suture was designed with a diameter of 0.300-0.349mm.

[0071] S2. Measure the braided silk suture, dip in the mixed solution of lithium bromide solution and BDDE, and prepare a hydrogel on its surface after partially dissolving. Orthogonal tests were carried out on the concentration of lithium bromide, the ratio of lithium bromide to suture, the amount of BDDE added to lithium bromide, the reaction temperature and the reaction time:

[0072] Lithium bromide concentration: 1M, 2M, 3M, 4M, 5M...

Embodiment 3

[0079] Embodiment 3 Utilizes melting layer to form composite hydrogel coating on the surface of silk suture

[0080] S1, prepare melted layer according to embodiment 1, specific conditions are as follows:

[0081] Lithium bromide concentration when the molten layer is formed: 7M;

[0082] The ratio of suture to lithium bromide: 1g: 10mL;

[0083] LiBr to BDDE: 1g: 200μL;

[0084] Time: 3 minutes;

[0085] Temperature: 25°C.

[0086] S2. Dip coating in natural polymer solution:

[0087] Silk fibroin solution concentration: 0.5mg / mL, 1mg / mL, 4mg / mL, 7mg / mL, 10mg / mL, 15mg / mL, 20mg / mL, 25mg / mL, 50mg / mL, 75mg / mL, 100mg / mL , 120mg / mL, 125mg / mL, 150mg / mL, 175mg / mL, 200mg / mL, 250mg / mL, 300mg / mL. Silk fibroin ratio BDDE: 1g: 200μL. See figure 2 .

[0088] Concentration of hyaluronic acid solution: 0.5mg / mL, 1mg / mL, 4mg / mL, 7mg / mL, 10mg / mL, 15mg / mL, 20mg / mL, 25mg / mL, 50mg / mL, 75mg / mL, 100mg / mL, 120mg / mL, 125mg / mL, 150mg / mL, 175mg / mL, 200mg / mL, 250mg / mL, 300mg / mL. Hyaluronic a...

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Abstract

The invention relates to a suture line with a gel coating. A surface of a suture line is partially dissolved to form a melt layer, one end of a part of molecules is free, the other end of the part of molecules is still fixed on the suture line, and then the hydrogel layer is formed on the surface of the suture line through self-crosslinking of the molecules and / or crosslinking of the molecules and other substances, so that the suture line is obtained. The suture line prepared by the invention overcomes problems of weak combination of a coating and a suture line and rough surface of the suture line, can greatly reduce friction and pulling between tissues in a suture process and after the suture process, is convenient for loading drugs, bioactive preparations and the like, effectively delays or releases the loaded substances, and promotes healing of damaged tissues.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a suture with gel coating and a preparation method thereof. Background technique [0002] Sutures are a special class of fiber-based threads that exist as monofilaments or multifilaments and are designed to degrade or remain permanently in the body. A variety of materials have been invented and used for surgical sutures, including plastics (degradable polyglycol and polylactic acid or nondegradable nylon and polypropylene), biologically derived proteins (collagen and silk), and metals (stainless steel and nickel Titano). Sutures have been widely used in many branches of medicine such as wound closure and anastomosis. But people are not satisfied with the simple wound suturing of suture thread and the effect of promoting healing, and hope to develop a suture product with low harm and high efficiency. There are also many studies focusing on different types of medica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/00A61L17/14
CPCA61L17/005A61L17/145A61L2300/414A61L2300/404A61L2300/41A61L2300/412
Inventor 郑兆柱王文君汪涛方岩李刚卢神州王晓沁
Owner SUZHOU UNIV
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