Construction method of type 2 diabetes primate model
A primate and construction method technology, applied in the field of construction of a type 2 diabetes primate model, can solve the problems of low modeling efficiency, long induction period of high-sugar and high-fat diet, not being a type 2 diabetes model, etc. achieve obvious effect
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[0022] A method for constructing a type 2 diabetes primate model, comprising the following steps:
[0023] Randomly select a group of 14-18-year-old experimental monkeys (cynomolgus cynomolgus, Macaca fascicularis, purchased from Guangxi Guidong Primate Development Experiment Co., Ltd.), and eliminate some individuals who may belong to spontaneous diabetes by measuring fasting blood glucose (FPG≥ 4.5). 90 animals with normal fasting blood glucose were left and randomly divided into 3 groups. The first group was the normal control group, and the lights were turned off from 20:00 to 6:00 the next day; From 20:00 to 6:00 the next day; the third group (experimental group) was given high-sugar and high-fat feed and changed the light-off time of the feeding room. The specific method was that the light-off time of the cage was 2:00-12:00. After one week, it will be adjusted to the normal light-off time from 20:00 to 6:00 the next day, and after another two weeks, it will be adjusted...
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