Antibacterial peptide and application thereof

Abstract

The invention discloses an antibacterial peptide and application thereof, and belongs to the technical field of biological medicine. According to the antibacterial peptide disclosed by the invention, the amino acid sequence of the antibacterial peptide is Glu-Leu-Leu-His-Leu-Leu-His-His-Leu-Leu-His-His. The invention also provides an antibacterial peptide derivative and an antibacterial peptide complex, and the antibacterial peptide, the antibacterial peptide derivative and the antibacterial peptide complex provided by the invention take polypeptide as a main body, have good biological safety and are not easy to cause drug resistance; the dental cariogenic bacteria in the decayed teeth can be effectively inhibited, and the dental cariogenic bacteria are not sensitive to the symbiotic bacteria in the decayed teeth, so that the antibacterial peptide has a selective antibacterial effect, the microecological balance of bacterial colonies in the decayed teeth can be adjusted, and the advantages of the symbiotic bacteria in a biological membrane are improved; meanwhile, the polypeptide also has pH response capability, can generate intelligent response to an acidic pathological environment, plays a role in a decayed tooth acidic microenvironment, and also can be used for preparing medicines for other acidic pathological environment diseases.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an antibacterial peptide and its application. Background technique [0002] Dental caries is the most common oral disease, and it is listed by the World Health Organization as one of the three major human diseases for prevention and treatment together with cardiovascular diseases and tumors. The fourth national oral health epidemiological survey showed that the prevalence of dental caries in my country is on the rise. If dental caries cannot be controlled in time, it may lead to consequences such as pulpitis, periodontitis, jaw infection and tooth loss, which will affect the health of the whole body and the quality of life. At the same time, the related treatment will increase the economic burden. Therefore, safe and effective anti-caries technology has considerable health and economic benefits. [0003] Modern caries etiology believes that under normal conditio...

AI Technical Summary

Problems solved by technology

Related technologies have confirmed the anti-cariogenic effects of various antimicrobial peptides, but most of them are based on their broad-spectrum antibacterial ability, which can also produce obvious inhibitory effects on commensal bacteria; The role of antimicrobial peptides in the mixed system of cariogenic bacteria and commensal bacteria is unknown, and there is still a risk of destroying the oral flora ecology of antimicrobial peptides in caries prevention, which limits the clinical application of antimicrobial peptides in caries prevention

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