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Experimental method for determining durability of Pharmacopoeia method by using content of huaijiao pills

An experimental method, the technology of Huaijiao pills, applied in the field of drug research, can solve the problems of poor durability, inseparable separation, uncommon chromatographic columns, etc., and achieve the effect of strong durability and poor durability.

Inactive Publication Date: 2021-11-19
HENAN RUNHONG HERBAL PHARMA
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Problems solved by technology

[0004] According to the 2015 edition of "Chinese Pharmacopoeia", the content analysis of Huaijiao Pills was carried out to verify the durability of its content determination method for different brands of chromatographic columns. Determination and analysis, it is found that different brands of phenyl columns have different results when the content determination analysis is carried out according to the pharmacopoeia method, and individual components cannot be separated. Therefore, it can be concluded that the pharmacopoeia method for the content determination of Huaijiao Pills in the 2015 edition of "Chinese Pharmacopoeia" The chromatographic column is not universal and has poor durability. In view of the above situation, an experimental method for the durability of the pharmacopoeia method for determining the content of Huaijiao Pills is proposed to verify the detection method that can accurately determine the content of Huaijiao Pills

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  • Experimental method for determining durability of Pharmacopoeia method by using content of huaijiao pills
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  • Experimental method for determining durability of Pharmacopoeia method by using content of huaijiao pills

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Embodiment

[0054] see Figure 1-8, the present invention provides the following technical scheme: Huaijiao Pill content determination experimental method of pharmacopoeia method durability, it is characterized in that: experimental material is as follows:

[0055] Henan Runhong Herbal Pharmaceutical Co., Ltd. Huaijiao Pills 171107, 180101, 180202, 180303, 190101, 190202, 190303, sophoridoside reference substance (batch number: 111695-201703, China Institute for Food and Drug Control), naringin reference substance ( Batch number: 110722-201815, China Institute for Food and Drug Control), baicalin reference substance (batch number: 110715-201720, China Food and Drug Control Institute);

[0056] Reagents: Methanol (batch number: 20181107, Tianjin Kemiou Chemical Reagent Co., Ltd.), acetonitrile (batch number: 20181127001, Tianjin Safer Technology Co., Ltd.), glacial acetic acid (batch number: 20170103, Tianjin Fuyu Fine Chemical Co., Ltd.), pure water;

[0057] Instruments: Ultrasonic mac...

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Abstract

The invention belongs to the technical field of medicine research, particularly relates to an experimental method for determining the durability of a pharmacopoeia method by using the content of huaijiao pills, and provides the following detection method for detecting the content of huaijiao pills: bonded phenyl porous silica gel microspheres serve as a filling agent (ChromCoreTM Phenyl 5 [mu]m 4.6*150mm); a 2% glacial acetic acid solution is used as a mobile phase A, a methanol-acetonitrile (2:1) mixed solution is used as a mobile phase B, and the flow velocity is 1.2 ml per minute; the detection wavelength of sophoricoside is 260 nm, and the detection wavelength of naringin and baicalin is 280 nm, and the column temperature is 50 DEG C. According to the present invention, the test on the huaijiao pill content detection method in the 2015 Chinese Pharmacopoeia finds that the result difference is large when the content of the same sample is determined by using the phenyl columns of different brands, the method capable of accurately detecting the huaijiao pill content data is provided according to the experiment result, and the durability is strong, and the method is worthy of vigorous promotion.

Description

technical field [0001] The invention belongs to the technical field of drug research, and in particular relates to an experimental method for determining the durability of a pharmacopoeia method for content determination of Huaijiao Pills. Background technique [0002] Huaijiao Pills are made from 200g Huaijiao (stir-fried), 100g Burnet charcoal, 100g Scutellaria baicalensis, 100g fried Fructus Aurantii Fructus with bran, 100g Angelica sinensis, 100g Fangfeng. Good medicine, mainly used for intestinal wind and blood in stool, hemorrhoid swelling and pain caused by blood heat. [0003] In the process of production inspection, it was found that the results of the determination of the content of the same sample with different brands of phenyl columns were quite different. Therefore, this test explored the applicability of the chromatographic column and the durability of the pharmacopoeia method to make a contribution to the quality of the drugs entering the market. ensure. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 乔辰龙王保峰
Owner HENAN RUNHONG HERBAL PHARMA
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