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Preparation method of chitosan oligosaccharide, chitosan oligosaccharide and chitosan oligosaccharide health-care product

A technology of chitosan oligosaccharides and health care products, which is applied in the field of preparation of health care products, can solve problems such as side reactions at the electrode, operational hazards, etc., and achieve the effect of reducing dosage and increasing application prospects

Pending Publication Date: 2021-11-12
吴洪德 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the high voltage of the pulsed electric field is likely to bring operational hazards, and a large number of side reactions are prone to occur at the electrodes

Method used

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  • Preparation method of chitosan oligosaccharide, chitosan oligosaccharide and chitosan oligosaccharide health-care product

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preparation example Construction

[0026] like figure 1 The preparation method of the chitosan oligosaccharide of one embodiment, comprises the steps:

[0027] S10, preparing a mixed reactant.

[0028] Specifically, the mixed reactant contains 10wt%-30wt% chitosan, 2wt%-6wt% acid and 3wt%-6wt% hydrogen peroxide.

[0029] Generally speaking, chitosan can choose chitosan with a molecular weight of 300KDa-580KDa and a deacetylation degree of 70%-90%.

[0030] Preferably, the mixed reactant contains 15wt%-25wt% chitosan.

[0031] Generally, the acid can be hydrochloric acid or acetic acid.

[0032] In other embodiments, other types of acids may also be selected.

[0033] Preferably, the operation of preparing the mixed reactant is: mixing the chitosan and acid solution, and then adding the hydrogen peroxide solution to obtain the mixed reactant.

[0034] S20. Place the mixed reactants in a high-frequency alternating magnetic field, and stir the mixed reactants for the first time at a stirring speed of 100 rpm ...

Embodiment 1

[0060] Mix chitosan with a molecular weight of 500KDa and a deacetylation degree of 85% and a 10wt% hydrochloric acid solution, and then add a 10wt% hydrogen peroxide solution to obtain a mixed reactant. The mixed reactant contained 20wt% chitosan, 5wt% acid and 5wt% hydrogen peroxide.

[0061] Place the mixed reactants in a high-frequency alternating magnetic field controlled by a high-frequency magnetic field generator, stir the mixed reactants for the first time at 60°C at a stirring speed of 300rpm for 6h, and control the plane formed by the first stirring and the high-frequency alternating Change the magnetic field to be vertical to obtain the first reaction solution. Wherein, the magnetic field strength of the high-frequency alternating magnetic field is 300 mT, and the frequency of the high-frequency alternating magnetic field is 250 KHz.

[0062] Add acid and hydrogen peroxide to the first reaction liquid, so that the first reaction liquid contains 5wt% acid and 5wt% ...

Embodiment 2

[0066] Mix chitosan with a molecular weight of 500KDa and a deacetylation degree of 85% and a 10wt% hydrochloric acid solution, and then add a 10wt% hydrogen peroxide solution to obtain a mixed reactant. The mixed reactant contained 20wt% chitosan, 5wt% acid and 5wt% hydrogen peroxide.

[0067] Place the mixed reactants in a high-frequency alternating magnetic field controlled by a high-frequency magnetic field generator, stir the mixed reactants for the first time at 60°C at a stirring speed of 300rpm for 6h, and control the plane formed by the first stirring and the high-frequency alternating Change the magnetic field to be vertical to obtain the first reaction solution. Wherein, the magnetic field strength of the high-frequency alternating magnetic field is 200 mT, and the frequency of the high-frequency alternating magnetic field is 120 KHz.

[0068] Add acid and hydrogen peroxide to the first reaction liquid, so that the first reaction liquid contains 5wt% acid and 5wt% ...

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Abstract

The invention discloses a preparation method of chitosan oligosaccharide, the chitosan oligosaccharide and a chitosan oligosaccharide health-care product. The preparation method comprises the following steps: preparing a mixed reactant containing chitosan, acid and hydrogen peroxide; placing the mixed reactant in a high-frequency alternating magnetic field, and stirring for the first time to obtain a first reaction solution; supplementing acid and hydrogen peroxide; placing the first reaction solution in a high-frequency alternating magnetic field, and stirring for the second time to obtain a second reaction solution; and separating and purifying to obtain the chitosan oligosaccharide. According to the preparation method of the chitosan oligosaccharide, a mixed reactant containing chitosan, acid and hydrogen peroxide is stirred under a high-frequency alternating magnetic field, and the magnetic field is cut by the mixed reactant to form current, so chemical degradation of the chitosan is matched. The preparation method of the chitosan oligosaccharide reduces the use amount of acid and hydrogen peroxide, does not need a high-voltage electric field, is an environment-friendly and safe preparation method of the chitosan oligosaccharide, and has a great application prospect.

Description

technical field [0001] The invention relates to the technical field of preparation of health products, in particular to a preparation method of oligochitosan, oligochitosan and health products of oligochitosan. Background technique [0002] Chitin is a polysaccharide linked by N-acetyl-2-amino-2-deoxy-D-glucose (abbreviated as N-acetylglucosamine, GlcNAc) with β-(1,4) glycosidic bonds. Hundreds of thousands to millions. Chitin is rich in sources, mainly obtained from crustacea shrimp and crab shells, insect shells, microbial cell walls, and plant (such as mushroom) cell walls. Its biosynthesis is estimated to be nearly 10 billion tons per year. The second largest biological resource after prime. [0003] Chitosan (chitosan) is obtained by removing the acetyl group on N from chitin under the action of concentrated alkali or deacetylase. Generally speaking, chitosan is chitin with a deacetylation degree of more than 55%, and the industrially used chitosan has a deacetylatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A23L33/125
CPCC08B37/003A23L33/125A23V2002/00A23V2200/30A23V2250/282
Inventor 吴洪德王亿鸿沈建华莫南海刘付海育
Owner 吴洪德
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