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Implant for non-luminal area

A technology for implants and regions, applied in the field of implants for non-luminal regions, can solve problems such as the inability to perform the functions of medical devices normally, and achieve the effects of excellent safety, improved corrosion resistance, and fine and uniform particle size

Pending Publication Date: 2021-11-09
JAPAN MEDICAL DEVICE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] On the other hand, the degradation rate of biodegradable materials in the body must be proportional to the regeneration rate of the tissue. If the degradation rate of the magnesium alloy is too fast, it will lose its stability before the damaged tissue recovers, and it will not be able to function normally. The original function of the device, on the other hand, if the degradation rate is too slow, it will cause problems such as complications

Method used

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  • Implant for non-luminal area

Examples

Experimental program
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Effect test

manufacture example 1 and manufacture example 2

[0122] As materials, high-purity raw metal lumps of Mg, Zn, Mn, and Zr were prepared. These high-purity raw material metal ingots were weighed and put into crucibles so that the respective metals had the component concentrations shown in Table 1, and the melts obtained by melting and stirring at 730°C were cast to produce ingots. , to obtain the magnesium alloys of Production Example 1 and Production Example 2 in which the proportion of the main components is within the scope of the present invention. Rare earth elements and aluminum, which are unavoidable impurities, are not contained in the raw materials used. As the magnesium raw metal block, a magnesium raw material block with a low concentration of impurity Cu and a purity of 99.99% is used, and iron and nickel are removed from the molten metal by performing iron removal treatment in a furnace. The impurity concentration of the sample obtained as described above was measured using an ICP emission spectrometer (manufactur...

manufacture example 3

[0132] As materials, high-purity raw metal lumps of Mg, Zn, Mn, and Zr were prepared. These high-purity raw metal ingots were weighed and put into crucibles so that each metal had the component concentrations described below, and the melts obtained by melting and stirring at 730° C. were cast to produce ingots. Rare earth elements and aluminum, which are unavoidable impurities, are not contained in the raw materials used.

[0133] As the magnesium raw metal block, a magnesium raw metal block with a low concentration of impurity Cu and a purity of 99.9% was used, and iron removal treatment was performed in a furnace to remove iron and nickel from the molten metal.

[0134] The impurity concentration of the obtained ingot was measured using an ICP emission spectrometer (manufactured by Agilent Technologies, Inc., AGILENT 720ICP-OES).

[0135] The component concentration (mass %) of the obtained ingot was as follows, and did not contain aluminum and rare earth.

[0136] The rem...

Embodiment 1

[0149] The mirror-like magnesium alloy substrate A was immersed in a 27M hydrofluoric acid aqueous solution and shaken at 100 rpm. The sample taken out after 24 hours was sufficiently ultrasonically cleaned with water and acetone, and then dried at 60° C. under reduced pressure for 24 hours to obtain a sample in which a magnesium fluoride layer (thickness 1 μm) was formed. A parylene C layer with a thickness of 500 nm was formed on the sample by CVD to obtain a sample having a parylene layer on the magnesium fluoride layer.

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Abstract

A non-luminal area implant with improved corrosion resistance, and a manufacturing method thereof are provided. (1) A magnesium alloy surface having a prescribed shape is fluorinated to form a fluorinated layer and a parylene layer is formed on the fluorinated layer to form this non-luminal area implant, which, on the magnesium alloy surface, has (a) a magnesium fluoride layer and (b) a parylene layer. (2) In a manufacturing method of this non-luminal area implant, (a) a magnesium alloy surface having an arbitrary shape is fluorinated to form a magnesium fluoride layer, and thereafter, (b) a para-xylylene resin is vapor deposited on the magnesium fluoride layer to form the parylene layer.

Description

[0001] related application [0002] This application claims the priority of Japanese Patent Application No. 2019-062874 filed in Japan on March 28, 2019 and Japanese Patent Application No. 2020-001520 filed in Japan on January 8, 2020, the entire contents of which are incorporated herein by reference It is incorporated as part of this application. technical field [0003] The present invention relates to an implant for a non-luminal area composed of a magnesium alloy whose surface is modified by coating the surface of a biodegradable magnesium alloy with a corrosion inhibiting layer. [0004] The implant for a non-luminal region of the present invention can be used as an implant for orthopedic surgery, oral surgery, orthopedic surgery, or brain surgery. Background technique [0005] In modern medical technology, implants are widely used as supports for surgical purposes, or for attaching or fixing tissue or bone. However, the implant remaining in the human body after the o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/04C23C28/00A61L31/02A61L31/08A61L31/10A61L31/12A61L27/30
CPCA61L31/10C22C23/04C23C28/00C23C22/34B05D1/60B05D2202/20B05D2350/60A61L31/022A61L31/088A61L31/148A61L2300/608A61L2430/02C25F3/18C08L65/04A61L27/047A61L27/306A61L27/58A61L2420/02A61L2430/12
Inventor 山下修藏佐佐木诚和田晃
Owner JAPAN MEDICAL DEVICE TECH
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