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Composition of withaferin A and leptin and application of composition to preparation of medicine for preventing and/or treating hemorrhagic stroke

A technology of hemorrhagic stroke and withaferin, which is applied in the field of the composition of withaferin A and leptin, can solve problems such as failure to effectively improve cerebral edema

Pending Publication Date: 2021-11-05
廖儒佳
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is worth noting that in this study, administration of stat3 inhibitors after cerebral hemorrhage failed to effectively improve cerebral edema and cerebral hemorrhage. This contradictory result shows that the role of leptin in cerebral hemorrhage needs to be further analyzed

Method used

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  • Composition of withaferin A and leptin and application of composition to preparation of medicine for preventing and/or treating hemorrhagic stroke
  • Composition of withaferin A and leptin and application of composition to preparation of medicine for preventing and/or treating hemorrhagic stroke
  • Composition of withaferin A and leptin and application of composition to preparation of medicine for preventing and/or treating hemorrhagic stroke

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Effect test

Embodiment 1

[0025] The mice used in the following examples are: 7-8 week-old male SPF grade C57 BL / 6 mice, purchased from Changsha Slack Experimental Animal Co., Ltd., production license number: SCXK (Xiang) 2016-0002. The animals were kept in the SPF level experimental animal center of the Affiliated Hospital of Guilin Medical College. The temperature of the experimental animal room was 20-26°C (daily temperature difference ≤4°C), the humidity was 40%-70%, and the lighting was 12h:12h alternately.

[0026] Establishment of hemorrhagic stroke model in mice: Male C57BL / 6 mice were anesthetized by intraperitoneal injection of 10% chloral hydrate (40 mg / kg). After anesthesia, the mouse was fixed on a stereotaxic apparatus, and the needle entry point of the right basal ganglia was located according to the mouse brain atlas. -3. 0 mm. Drill a hole to the dura mater, depilate the tail of the mouse, rub the tail blood vessels with alcohol to expand, and press the root of the tail at the same ti...

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Abstract

The invention relates to a composition of withaferin A and leptin and an application of the composition to preparation of a medicine for preventing and / or treating hemorrhagic stroke, and belongs to the technical field of medicines. The invention provides the composition of the withaferin A and leptin and the application of the composition to preparation of the medicine for preventing and / or treating hemorrhagic stroke. The two existing compounds of the withaferin A and the leptin are applied to preparation of the medicine for preventing and / or treating hemorrhagic stroke through combinatorial optimization. The invention not only provides a new source for preparing the medicine for preventing and / or treating hemorrhagic stroke, but also explores new medicinal values of the withaferin A and the leptin. The technology disclosed by the invention is subsidized by the Guangxi science and technology base and the special talent fund (Guike AD18281013) and the Gangxi natural science fund youth fund (2018GXNSFBA138046) of the Gangxi natural science fund surface project (2020GXNSFA259036).

Description

technical field [0001] The invention relates to a composition of withaferin A and leptin and its application in the preparation of medicines for preventing and or treating hemorrhagic stroke, belonging to the technical field of medicine. Background technique [0002] Hemorrhagic stroke is a sudden-onset blood circulation disorder, clinically manifested as transient or permanent dysfunction, and is an important type of stroke, accounting for about 15%. Cerebral hemorrhage deaths in the Chinese population account for about 61.7% of cerebrovascular disease deaths, and its high morbidity and mortality have become the leading cause of death among Chinese people. Although great progress has been made in the pathophysiological research of cerebral hemorrhage, effective treatment methods are still limited to surgical removal of hematoma, dehydration, reduction of intracranial pressure, and neuroprotection. From the curative effect point of view, whether it is surgical treatment or ...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61P9/10A61P25/00A61K31/585
CPCA61K31/585A61K38/2264A61P9/10A61P25/00A61K2300/00
Inventor 廖儒佳李清华周紫贤蒋艳林陈梅玲邓俊刚田宁
Owner 廖儒佳
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