High-viscosity extrusion jet sample loading device for protein crystal structure analysis

A crystal-structured, high-viscosity technology, used in measurement devices, material analysis using wave/particle radiation, and material analysis, to achieve good application prospects, improve compatibility, and reduce construction difficulty.

Pending Publication Date: 2021-11-02
SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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Problems solved by technology

[0004] The purpose of the present invention is to provide a high-viscosity extrusion injection sample loading device for protein crystal structure analysis, thereby solving the problems of compatibility in the existing high-viscosity extrusion injection technology

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  • High-viscosity extrusion jet sample loading device for protein crystal structure analysis
  • High-viscosity extrusion jet sample loading device for protein crystal structure analysis
  • High-viscosity extrusion jet sample loading device for protein crystal structure analysis

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with specific embodiments. It should be understood that the following examples are only used to illustrate the present invention but not to limit the scope of the present invention.

[0033] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation indicated by rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc. The positional relationship is based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as limiti...

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Abstract

The invention provides a high-viscosity extrusion jet sample loading device for protein crystal structure analysis. The high-viscosity extrusion jet sample loading device comprises: a liquid inlet section connected with a hydraulic device; a piston section which is connected with the liquid inlet section and comprises a piston rod which reciprocates in the piston section; a sample section connected to the piston section, wherein the one end of the piston rod is in contact with liquid input by the liquid inlet section, and the other end of the piston rod is in contact with a viscous sample in the sample section; an air inlet section which is connected with the sample section through a capillary tube; an intersection section which is connected with the gas inlet section, wherein gas from the gas inlet section focuses the viscous sample extruded from the capillary tube into stable jet flow through shear force, and the stable jet flow is kept at the intersection section to interact with the X-ray; a recovery section which is connected with the intersection section; a fixed section which is connected with the intersection section; and an off-line separation section insertable between the sample section and the intake section. The device not only can be used for collecting crystal serial data, but also can be used for time resolution experiments of protein crystals, and has a good application prospect in the field of protein crystal structure analysis.

Description

technical field [0001] The invention relates to the field of protein crystal structure analysis, in particular to a high-viscosity extrusion injection sample loading device for protein crystal structure analysis. Background technique [0002] With the development of structural biology, efficient and stable sample loading methods are becoming more and more important. Simple fixed target sample loading technology can no longer meet the needs of crystal structure analysis. Mobile phase sample loading technology has been widely developed. Confinement technology means that the crystal itself performs migration motion to transmit to the X-ray optical path. The existing technologies mainly include: gas focusing dynamic virtual nozzle (GDVN), high viscosity extrusion ejector (HVE), microfluidic electric sample holder (MESH), capillary Technology (Capillary), Aerosol injector (Aerosol injector), Acoustic Droplet Ejection (ADE). Compared with fixed target technology, the advantage of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N23/207G01N23/20008
CPCG01N23/207G01N23/20008
Inventor 梁淼汪启胜王志军何建华刘科
Owner SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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