Specific marker screening method for detecting azoospermia and severe oligospermia

A technology for oligospermia and azoospermia, which is applied in the field of specific marker screening, can solve the problems of time-consuming, time-consuming, and labor-intensive detection, and achieve the effect of avoiding invalid or unnecessary examination and treatment

Pending Publication Date: 2021-11-02
JILIN UNIV
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  • Abstract
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Problems solved by technology

Traditional gel electrophoresis is time-consuming, labor-intensive, and polluting
[0005] Through the above analysis, the problems and defects of the existing technology are: the detection time of the existing technology is long, the efficiency is low, and it can only explain the cause of spermatogenesis disorder in a small number of patients

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  • Specific marker screening method for detecting azoospermia and severe oligospermia

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Embodiment Construction

[0031] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0032] Aiming at the problems existing in the prior art, the present invention provides a rapid detection method for specific markers of azoospermia and severe oligospermia. The present invention will be described in detail below with reference to the accompanying drawings.

[0033] Those of ordinary skill in the industry can also use other steps to implement the rapid detection method for specific markers of azoospermia and severe oligospermia provided by the present invention, figure 1 The rapid detection method for specific markers of azoospermia and severe oligospermia provided by the present invention is only a specifi...

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Abstract

The invention belongs to the technical field of medical detection, and discloses a specific marker screening method for detecting azoospermia and severe oligospermia. The method comprises the following steps: collecting a sample, treating the sample, and screening out specific markers of the severe oligospermia and azoospermia; in a testicular tissue level, screening expression of differential microRNA in testicular tissues of normal males and sterile males by using a chip method; in a seminal plasma layer, searching differential marker proteins of normal males and sterile males by using a proteomics method; in the urine level, employing metabonomics for screening the difference of metabolites in urine of normal men and infertility men; integrating data obtained from three high-flux layers, namely a testis tissue layer, a seminal plasma layer and a urine layer, and carrying out correlation analysis on the data and sperm quality, density and vitality; and optimizing and establishing a diagnosis technology. The method is long in detection time, high in efficiency and capable of explaining the cause of dyszoospermia of the patient.

Description

technical field [0001] The invention belongs to the technical field of medical detection, and in particular relates to a specific marker screening method for detection of azoospermia and severe oligospermia. Background technique [0002] At present, the etiology of spermatogenic disorders in most patients with azoospermia and severe oligospermia is unknown, which brings great confusion to clinical treatment. Therefore, there is an urgent need to conduct systematic research on the mechanism of unexplained spermatogenic disorders, screen for specific markers of azoospermia and severe oligospermia, and develop related rapid detection technologies, so as to provide rapid and accurate clinical typing and personalized treatment for male infertility patients. Treatment provides evidence to reduce ineffective or unnecessary examinations and treatments. At present, the development status of related technologies at home and abroad is as follows: the clinical detection methods of azoo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/686G01N33/68
CPCC12Q1/6883C12Q1/686G01N33/6893C12Q2600/158C12Q2600/178C12Q2561/113
Inventor 郑连文马帅徐影赵东海陈晓晨付璐璐
Owner JILIN UNIV
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