Application of reagent for detecting expression levels of two biomarkers in sample in preparation of kit for detecting preeclampsia

Abstract

According to the invention, the ratio of biomarkers leptin to ceramide related to preeclampsia is found for the first time, and early diagnosis of preeclampsia is realized by detecting the level change of the ratio of leptin to ceramide of a subject. The method can be used for evaluating the preeclampsia disease risk during pregnancy, has high accuracy and specificity, and provides an effective method for early prediction and precise prevention of preeclampsia. In the early stage of morbidity, timely and accurate auxiliary diagnosis is carried out on pregnant women with preeclampsia risks, clinical close monitoring on patients is helped, effective intervention is timely carried out to control the illness state and prolong the gestational week, and the method has important significance in reducing the preeclampsia morbidity and mortality rate and guaranteeing the safety of mothers and infants.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of a reagent for detecting the expression levels of two biomarkers in a sample in the preparation of a kit for detecting preeclampsia. Background technique [0002] Preeclampsia, also known as preeclampsia (PE), is a serious multisystem complication of pregnancy that has adverse effects on both mother and baby. The incidence of the disease accounts for about 5-8% of all pregnancies in China and globally, the disease is responsible for 18% of all maternal deaths worldwide, and is also the leading cause of fetal and neonatal deaths. In medicine, patients with preeclampsia or the risk of preeclampsia are called preeclampsia patients. Clinical presentation is variable, but hypertension and proteinuria are often seen. The characteristics are as follows: new-onset hypertension and proteinuria after 20 weeks; with or without thrombocytopenia, renal function damage, liver functi...

AI Technical Summary

Problems solved by technology

The causes and pathogenesis of preeclampsia remain uncertain, and diagnosis relies on laboratory and clinical signs and symptoms that develop later in the nonspecific course, making diagnostic and clinical management decisions difficult

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