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Application of progestational hormone in preparation of medicine for inhibiting cytokine storm

A technology of cytokines and cell inhibition, which is applied in the field of treatment of immune diseases and infectious diseases, and can solve problems such as no clear treatment guidelines and unclear pathophysiological mechanisms

Active Publication Date: 2021-10-29
SHENZHEN EVERGREEN THERAPEUTICS CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]Currently, the specific pathophysiological mechanism of cytokine storm syndrome is still unclear (it is speculated that it is related to cytolytic immune response), and there is no specific corresponding drug for treatment. Most of the clinical management experience of cytokine storm syndrome comes from CRS symptoms caused by immunotherapy, especially adoptive cell therapy. In influenza virus and coronavirus infection, there is no clear treatment guideline, and it has been tried to treat cytokine storm syndrome. Medications for storm syndrome include peroxisome proliferator-activated receptor agonists, sphingosine-1-phosphate receptor agonists, cyclooxygenase inhibitors, antioxidants, anti-tumor necrosis factor therapy, intravenous Immunoglobulin and other therapies

Method used

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  • Application of progestational hormone in preparation of medicine for inhibiting cytokine storm
  • Application of progestational hormone in preparation of medicine for inhibiting cytokine storm
  • Application of progestational hormone in preparation of medicine for inhibiting cytokine storm

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Embodiment Construction

[0019] Test animals and materials:

[0020] Humanized mice bred under specific pathogen-free conditions were used in the experiments. All experimental procedures were approved by the Animal Ethics Committee. All antibodies used for flow cytometric analysis were purchased from outside sources. The endotoxin levels of these antibodies were all less than 0.5 IU / mg.

[0021] Human peripheral blood mononuclear cells (PBMCs) were also used in this experiment. Wash the isolated human PBMCs with phosphate buffered saline first. After lysing the red blood cells, the nucleated cells were washed three more times with phosphate buffered saline.

[0022] Test method and process:

[0023] In general, after 10 days of adoptive transplantation of human peripheral blood mononuclear cells (PBMC) (post-adaptive transfer), human CD45 cells in the spleen and blood of humanized severe combined immunodeficiency (hu-SCID) mice compared with mouse CD45 The ratio of cells was 3:1 and 0.4:1, respe...

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Abstract

The invention provides hydroxyprogesterone hexanoate for treating various diseases which cause the cytokine storm, such as COVID-19, infection of various virulent viruses, side effects after monoclonal antibody treatment, side effects after CAR-T treatment, inflammatory bowel diseases, pancreatitis and the like. Meanwhile, the invention also provides a method for treating the above diseases by using a corresponding medicine composition. Experimental results show that the progestational hormone hydroxyprogesterone hexanoate can effectively inhibit the cytokine storm and is expected to become an effective medicine for treating diseases such as the COVID-19 and the like.

Description

technical field [0001] The invention belongs to the field of treatment of immune diseases and infectious diseases. Specifically, the application provides the application of PR2005 in the preparation of drugs for inhibiting cytokine storms, especially cytokine storms caused by diseases such as new coronavirus pneumonia. Background technique [0002] Immune cells communicate with each other through cytokines. Cytokines are small molecules released by cells into the blood, which can cause immune cells to move infection sites, phagocytize damaged cells, and even penetrate blood vessel walls; at the same time, cytokines can also trigger inflammation, causing the damaged body to swell, heat and pain. [0003] When the immune system is activated to the limit or out of control due to factors such as infection, CART treatment, certain drugs, or autoimmune regulation imbalance, it releases a large number of various cytokines, and the level of a large number of pro-inflammatory cytoki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61P31/14A61P11/00A61P31/12A61P37/06
CPCA61K31/57A61P31/14A61P11/00A61P31/12A61P37/06A61P31/00A61P31/06C07K16/2809A61K2039/505C07K2317/75A61K39/39541Y02A50/30A61K2300/00
Inventor 杜涛杜新
Owner SHENZHEN EVERGREEN THERAPEUTICS CO LTD
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