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Preparation of honeysuckle flower extract and application of honeysuckle flower extract in toothpaste

A honeysuckle extract and technology of honeysuckle, applied in the direction of medical preparations containing active ingredients, dentistry, cosmetic preparations, etc., can solve the problems of large structural damage, protein denaturation and inactivation, periodontal tissue and oral mucosa damage, etc. Achieve the effect of low cost, high polysaccharide extraction rate and simple operation

Active Publication Date: 2021-10-22
贵州苗老藤化妆品生产制造有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the key to the application of honeysuckle in toothpaste lies in its health care function, and in order to ensure the biological activity of honeysuckle polysaccharides, it is usually necessary to deproteinize the polysaccharides extracted from honeysuckle, and deproteinization will not only greatly damage the structure of polysaccharides, but honeysuckle polysaccharides There are very few studies on the influence of toothpaste texture and rheological properties. In addition, some studies have found that the most common surfactant in toothpaste, sodium dodecyl sulfate (SDS for short), has a strong affinity with proteins and can It denatures and inactivates the protein, and it inhibits the formation of acquired membranes. Long-term use may cause damage to periodontal tissue and oral mucosa, which greatly limits the application of SDS in toothpaste. Therefore, the inventors extract Technology research, in order to extract a toothpaste system that can cooperate with SDS to improve the rheology

Method used

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  • Preparation of honeysuckle flower extract and application of honeysuckle flower extract in toothpaste
  • Preparation of honeysuckle flower extract and application of honeysuckle flower extract in toothpaste
  • Preparation of honeysuckle flower extract and application of honeysuckle flower extract in toothpaste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of honeysuckle extract, comprising the steps of:

[0031] 1) Take fresh honeysuckle and put it into a drying machine for deenzyming, heat it at 120°C for 3 minutes, then dry it with hot air at 50°C for 10 minutes, and grind it until it passes through a 40-mesh sieve to obtain honeysuckle powder;

[0032] 2) Put the honeysuckle powder in water according to the mass ratio of solid: liquid = 1:10, and treat it under high pressure at 20 MPa for 3 minutes, then add 0.01% sodium lauryl sulfate of the honeysuckle powder and mix evenly, at 45°C Heat and extract for 10 minutes, centrifuge at 4000 rpm for 8 minutes, filter, and take filtrate A;

[0033] 3) Add absolute ethanol to the filtrate A until the alcohol content is 10%, let stand at 0°C for 1 hour, filter to remove the precipitate, and obtain filtrate B, add absolute ethanol to the filtrate B to reach the alcohol content of 50%, stand at 0°C After standing for 1 h, centrifuge at 4000 rpm for 8 min, d...

Embodiment 2

[0035] A preparation method of honeysuckle extract, comprising the steps of:

[0036] 1) Take fresh honeysuckle and put it into a deenzyming dryer, deactivate it at 130°C for 5 minutes, then dry it with hot air at 55°C for 15 minutes, grind it until it passes through a 50-mesh sieve, and obtain honeysuckle powder;

[0037] 2) Put the honeysuckle powder in water according to the mass ratio of solid: liquid = 1:20, and treat it under high pressure at 25MPa for 5 minutes, then add 0.05% sodium lauryl sulfate of the honeysuckle powder and mix evenly. Heat and extract for 15 minutes, centrifuge at 5000 rpm for 10 minutes, filter, and take filtrate A;

[0038] 3) Add absolute ethanol to the filtrate A until the alcohol content is 10%, let stand at 4°C for 2h, filter to remove the precipitate, and obtain filtrate B, add absolute ethanol to the filtrate B until the alcohol content is 50%, stand at 4°C After standing for 2 hours, centrifuge at 5000 rpm for 10 minutes, discard the supe...

Embodiment 3

[0040] A preparation method of honeysuckle extract, comprising the steps of:

[0041] 1) Take fresh honeysuckle and put it into a deenzyming dryer, deactivate it at 125°C for 4 minutes, then dry it with hot air at 52°C for 12 minutes, grind it until it passes through a 45-mesh sieve, and obtain honeysuckle powder;

[0042] 2) Put the honeysuckle powder in water according to the mass ratio of solid: liquid = 1:15, and treat it under high pressure at 22 MPa for 4 minutes, then add 0.03% sodium lauryl sulfate of the honeysuckle powder and mix evenly. Heat and extract for 12 minutes, centrifuge at 4500 rpm for 9 minutes, filter, and take filtrate A;

[0043] 3) Add absolute ethanol to the filtrate A until the alcohol content is 10%, let stand at 2°C for 1.5h, filter to remove the precipitate, and obtain the filtrate B, add absolute ethanol to the filtrate B until the alcohol content is 50%, set aside at 2°C After standing still for 1.5 h, centrifuge at 4500 rpm for 9 min, discard...

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Abstract

The invention belongs to the technical field of daily chemicals, and particularly relates to preparation of a honeysuckle flower extract and application of the honeysuckle flower extract in toothpaste. According to the invention, honeysuckle flower polysaccharide is extracted through a water extraction and alcohol precipitation method, and high-temperature fixation, hot air drying, grinding, high-pressure treatment, treatment with lauryl sodium sulfate and other means are combined, so an extraction temperature is reduced, and alcohol precipitation steps are decrased; and the obtained honeysuckle extract and sodium carboxymethyl cellulose form a compound system according to a mass ratio of 1: (3-4.5), and the compound system can serve as a toothpaste thickening agent to improve the rheological property of toothpaste, decrease the manufacturing cost of the toothpaste, lower irritation to the oral cavity and enhance stability and safety.

Description

technical field [0001] The invention belongs to the technical field of daily chemicals, and in particular relates to the preparation of a honeysuckle extract and its application in toothpaste. Background technique [0002] Honeysuckle has been hailed as a good medicine for clearing heat and detoxification since ancient times. It is sweet and cold in nature and fragrant. It is sweet and cold in clearing away heat without hurting the stomach. Many of the organic acids, flavonoids and polysaccharides contained in honeysuckle have anti-oxidation, anti-aging, antibacterial and anti-inflammatory effects. At present, toothpaste is formulated with the extract of the Chinese herbal medicine honeysuckle as the main ingredient, which has the functions of clearing away heat and fire, reducing inflammation, relieving pain and removing bad breath, and adding honeysuckle to the toothpaste, its unique fragrance, can also improve the feeling of use. [0003] At present, the key to the appli...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61Q11/00
CPCA61K8/9789A61K8/731A61Q11/00A61K2800/48
Inventor 严光华谢翠萍严伟蒋云汉
Owner 贵州苗老藤化妆品生产制造有限公司
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