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Synthesis method of vitamin C tetraisopalmitate

A technology of palmitic acid ester and synthesis method, which is applied in the direction of organic chemistry, can solve the problems of excessive waste gas, waste water and waste residue, unstable raw material prices, complex synthesis methods, etc., and achieve the effects of low production cost, consistent performance, and simple reaction

Pending Publication Date: 2021-10-12
南雄阳普医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the traditional synthetic method of vitamin C tetraisopalmitate is relatively complicated, and the price of the raw materials used is unstable, and it is easy to produce more waste gas, waste water and waste residue, which is not good for the environment. Therefore, it is urgent to study a low-cost A cost-effective and environmentally friendly synthetic method of vitamin C tetraisopalmitate

Method used

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  • Synthesis method of vitamin C tetraisopalmitate
  • Synthesis method of vitamin C tetraisopalmitate

Examples

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Embodiment 1

[0024] This embodiment provides a kind of synthetic method of vitamin C tetraisopalmitate, it comprises the following steps:

[0025] (1) 1 mol of vitamin C, aqueous sodium hydroxide solution and 7 mol of cyclohexane were mixed for 30 min, and placed in an ice bath at a temperature of 15° C., and then 3 mol of 2-hexyldecanoyl chloride ( Control the dropwise addition within 4 hours) to carry out the heat preservation reaction for 24 hours, and at the same time, an aqueous solution of sodium hydroxide can be added to make the reaction pH 9.5 to obtain a reaction solution. Wherein, the molar mass of sodium hydroxide in the aqueous solution of sodium hydroxide is 2mol.

[0026] (2) Pour the reaction solution into a separatory funnel and carry out static layering treatment for 0.1h, then take the upper layer to obtain the upper layer A.

[0027] (3) Add an aqueous oxalic acid solution with a mass concentration of 1% to the supernatant A for stratification, and take the upper layer...

Embodiment 2

[0031] This embodiment provides a kind of synthetic method of vitamin C tetraisopalmitate, it comprises the following steps:

[0032] (1) 1 mol of vitamin C, aqueous sodium hydroxide solution and 9 mol of cyclohexane were mixed for 30 min, and placed in an ice bath at a temperature of 5° C., and then 5 mol of 2-hexyldecanoyl chloride ( Control the dropwise addition within 4 hours) to carry out the heat preservation reaction for 24 hours, and at the same time, an aqueous solution of sodium hydroxide can be added to make the reaction pH 10 to obtain a reaction solution. Wherein, the molar mass of sodium hydroxide in the aqueous solution of sodium hydroxide is 4mol.

[0033] (2) Pour the reaction solution into a separatory funnel for static layering treatment for 1 h, then take the upper layer to obtain the upper layer A.

[0034] (3) Add an aqueous oxalic acid solution with a mass concentration of 3% to the supernatant A for stratification, and take the upper layer to obtain a ...

Embodiment 3

[0038] This embodiment provides a kind of synthetic method of vitamin C tetraisopalmitate, it comprises the following steps:

[0039] (1) 1 mol of vitamin C, aqueous sodium hydroxide solution and 8 mol of cyclohexane were mixed for 30 min, and placed in an ice bath at a temperature of 15° C., and then 4 mol of 2-hexyldecanoyl chloride ( Control the dropwise addition within 4 hours) to carry out the heat preservation reaction for 24 hours, and at the same time, an aqueous solution of sodium hydroxide can be added to make the reaction pH 9.8 to obtain a reaction solution. Wherein, the molar mass of sodium hydroxide in the aqueous solution of sodium hydroxide is 3mol.

[0040] (2) Pour the reaction solution into a separatory funnel and carry out static layering treatment for 0.5h, then take the upper layer to obtain the upper layer A.

[0041] (3) Add an aqueous oxalic acid solution with a mass concentration of 2% to the supernatant liquid A for stratification, and take the uppe...

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Abstract

The invention is suitable for the field of chemical synthesis, and provides a synthesis method of vitamin C tetraisopalmitate, which comprises the following steps: mixing vitamin C, an alkali solution and cyclohexane, carrying out ice bath treatment, and then dropwise adding 2-hexyldecanoyl chloride to carry out heat preservation reaction to obtain a reaction solution; carrying out standing layering treatment on the reaction solution, and taking an upper layer to obtain a supernatant A; adding an oxalic acid aqueous solution into the supernatant A for layering, and taking the upper layer to obtain a supernatant B; adding petroleum ether and a saturated sodium bicarbonate solution into the supernatant B for layering, and then adding a saturated sodium chloride solution for washing to obtain a clear solution; and adding a calcium carbonate viscous liquid into the clear solution, stirring and separating the liquid, and then adding activated carbon for purification to obtain the vitamin C tetraisopalmitate. The synthesis method provided by the invention is simple in reaction, the obtained product is high in purity, less waste water, waste gas and waste residue are generated, and the synthesis method is beneficial to the environment.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, in particular to a synthetic method of vitamin C tetraisopalmitate. Background technique [0002] Vitamin C tetraisopalmitate, also known as tetrahexyldecyl ascorbate or ascorbyl tetraisopalmitate, is an oil-soluble vitamin C derivative, which has anti-oxidation, melanin inhibition and whitening effects. C is synthesized as a raw material. [0003] However, the traditional synthesis method of vitamin C tetraisopalmitate is relatively complicated, and the price of the raw materials used is unstable, and it is easy to generate more waste gas, waste water and waste residue, which is not good for the environment. Therefore, it is urgent to study a low-cost A cost-effective and environmentally friendly synthesis method of vitamin C tetraisopalmitate. Contents of the invention [0004] The purpose of the embodiments of the present invention is to provide a synthetic method of vitamin C tetraisopal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/62
CPCC07D307/62
Inventor 何俊杰陈万能钟雄福钟永清
Owner 南雄阳普医疗科技有限公司
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