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Asymmetric bipolar cell fusion instrument based on HB-MMC and control method

A cell fusion, bipolar technology, applied in the methods of stress-stimulated microbial growth, biochemical equipment and methods, biochemical instruments, etc., to achieve the effect of improving fusion efficiency and reducing cell death rate

Pending Publication Date: 2021-10-08
CHONGQING UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the current bipolar cell fusion instruments are all of symmetrical polarity, but recent studies have found that asymmetric bipolar high-voltage pulses have greatly improved cell death rates and improved fusion efficiency, and have great potential in the field of biomedicine. Expansion capacity,

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  • Asymmetric bipolar cell fusion instrument based on HB-MMC and control method
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  • Asymmetric bipolar cell fusion instrument based on HB-MMC and control method

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Embodiment Construction

[0070] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0071]The invention provides an asymmetric bipolar cell fusion instrument based on HB-MMC, such as figure 1 As shown, it includes a housing, in which a pulse generating module, a sinusoidal generating module, a switching circuit and a controller module are arranged;

[0072] The signal output control terminal of the controller module is connected with the signal control input terminal of the pulse generation module, and the pulse generation module outputs a pulse voltage signal according to the control signal sent by the controller modul...

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Abstract

The invention provides an asymmetric bipolar cell fusion instrument based on HB-MMC and a control method; the asymmetric bipolar cell fusion instrument comprises a shell; a pulse generation module, a sine generation module, a switching circuit and a controller module are arranged in the shell; the controller module is connected with the pulse generation module; the sine generation module is connected with the controller module; the pulse generation module is connected with the switching circuit; the sine generation module is connected with the switching circuit; the switching circuit is connected with the controller module; and the switching circuit sends a pulse voltage signal or / and a sine voltage signal to a load according to a control signal sent by the controller module. Asymmetric adjustment of positive and negative polarity pulse amplitudes, pulse widths and numbers can be realized, so that the second asymmetric pulse can better reduce the action effect of the first pulse, the cell death rate is reduced, the fusion efficiency is improved, and great significance is achieved for the development of biomedical treatment and biopharmacy.

Description

technical field [0001] The invention relates to the technical field of cell fusion instruments, in particular to an HB-MMC-based asymmetric bipolar cell fusion instrument and a control method. Background technique [0002] Cell fusion can realize distant hybridization, and its significance lies in that it breaks the boundary of creating new species only by relying on limited hybridization recombination genes, and it is possible to form new hybrid animal or plant cells that cannot be obtained by sexual hybridization, expanding the scope of genetic material recombination . [0003] Cell fusion is an essential pathway for bioproduction. Whether cells can fuse effectively is the key to determining the feasibility of bio-production, and even becomes a bottleneck restricting the development of bio-production technology. Therefore, how to develop and improve the existing cell fusion methods and improve the effect and efficiency of cell fusion has become a research hotspot in the ...

Claims

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Application Information

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IPC IPC(8): C12M1/42C12M1/36C12M1/34
CPCC12M35/02C12M41/00
Inventor 沈婷李新皓柯强吴浩
Owner CHONGQING UNIV
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