Taste-masked oral membrane containing nano lignin and preparation method thereof

Abstract

The invention provides a taste-masked oral membrane containing nano lignin and a preparation method thereof. The taste-masked oral membrane contains nano cellulose, nano lignin, xylitol, polydopamine and pharmaceutical ingredients; the above materials are mixed and then subjected to strong mechanical stirring and strong ultrasonic treatment to be uniformly mixed, and the film-forming agent is obtained after bubble removal and drying. The nanocellulose is a film-forming main body material and a disintegration component; the nano lignin and the polydopamine have drug loading capacity; meanwhile, the nano lignin and the polydopamine both have a bonding function in the membrane structure, and instant dissolution or slow release of the membrane agent can be realized by regulating and controlling the dosage of the nano lignin and the polydopamine. Xylitol is used as a flavoring agent and has the function of preventing decayed teeth; the dissolving heat absorption makes the mouth cool and refreshing. The membrane agent is good in biodegradability, and the preparation method is simple and easy to implement. The membrane agent solves the problems of poor compliance of patients to bitter drugs and the like, and realizes high value-added application of the nano lignin derived from wood fibers in the field of oral membrane agents.

Description

technical field [0001] The invention relates to the application field of nano lignin, in particular to a flavor-correcting oral film containing nano lignin and a preparation method thereof. Background technique [0002] Oral film preparations are pharmaceutical preparations that can dissolve rapidly in the oral cavity by immobilizing the active ingredients of the drug on the film-forming material. Its feature is to achieve convenient medication, small size, easy to carry, no need for water delivery, and it can improve the compliance of patients, especially for the medication of young children, the elderly and patients with dysphagia. After the oral instant film adheres, it is not easy to spit out, and will not block the airway. It is relatively safe and does not easily cause the danger of choking. Flavor correction, also known as taste masking, refers to the purpose of masking the bitter taste of drugs by adding flavoring agents and other means, so as to achieve better drug...

AI Technical Summary

Problems solved by technology

[0004] At present, although the oral film has shown many advantages and has become a new drug preparation, the oral film based on nano-lignin of renewable natural product biomass and the oral film based on the regulation of nano-lignin and polydopamine to achieve drug release rate Membranes have not been reported