Applications of highland barley fermentation broth

A technology for fermentation broth and highland barley, which is applied in the directions of medical preparations containing active ingredients, cosmetic preparations, preparations for skin care, etc., to achieve the effects of stabilizing skin structure, easy control of conditions, and improving skin repairing activity

Pending Publication Date: 2021-09-28
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there are no relevant reports on the influence of barley fermented liquid on the expression levels of skin-related genes.

Method used

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  • Applications of highland barley fermentation broth
  • Applications of highland barley fermentation broth
  • Applications of highland barley fermentation broth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 highland barley fermented liquid

[0035] The base material of the fermentation product is highland barley, which is produced in Lhasa, Tibet, in the pan-Himalayan region. The highland barley grains containing the bran are washed with deionized water, dried, and powdered by a milling machine, and passed through a 20-100 mesh sieve to obtain the highland barley powder. Mix the highland barley powder with deionized water, and the content of the highland barley powder in the fermentation medium / culture solution is 4wt%; after high temperature and high pressure sterilization, use Saccharomyces cerevisiae for cooling to ferment under the conditions of 26~30°C and 150~250rpm 48 hours.

[0036] Preparation of barley fermented liquid:

[0037](1) Centrifuge the fermentation product at 4-10°C and 6000rpm for 10-30min, and take the supernatant;

[0038] (2) Adjust the pH to 5.0-7.0, bathe in water at 80-90°C for 30-60 minutes, centrifuge at 4000...

Embodiment 3

[0059] Example 3 Efficacy Test of Highland Barley Fermented Liquid on 3D Recombined Human Epidermis Model

[0060] The in vitro human recombinant epidermal model can simulate the growth cycle of normal human epidermis, and evaluate the safety and efficacy of the test substance through the proliferation and differentiation of epidermal keratinocytes and the structure and components of the epidermis.

[0061] Test Methods:

[0062] A 3D human recombinant epidermal model was constructed using a hanging cell culture chamber Transwell (Corning) matching a 12-well plate. When the human keratinocytes in the culture flask are expanded to 70-80% confluence, the cells are digested and harvested, the cells are resuspended with the 3D epidermis model culture medium, and inoculated into the Transwell. The 3D epidermis model was cultured in the submerged phase at the initial stage after inoculation, and the gas-liquid phase culture was started from the 4th day until the end. The experimen...

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Abstract

The invention belongs to the field of plant extraction and the field of daily chemicals, and specifically relates to applications of highland barley fermentation broth in preparation of an external preparation for skins. The highland barley fermentation broth serves as an anti-aging active ingredient in the external preparation for skins. According to the highland barley fermentation broth, by improving the expression of basal layer protein related genes, the expression of extracellular matrix related genes and the expression of anti-aging cell factor genes, the skin structure is stabilized, the repair activity of skins is improved, the skin aging is delayed, the epidermal cell activity is improved, and the epidermal thickness is increased, so that the anti-aging effects are realized. The highland barley fermentation broth is suitable for preparing external preparations for skins and has wide application prospects. The highland barley fermentation broth is simple in preparation process , easy in condition control, and low in production cost. The highland barley fermentation broth is high in activity, can generate a remarkable effect under a low content, adopts pure natural, safe and non-irritant raw materials, and is widely applied to various skin external preparations.

Description

technical field [0001] The invention belongs to the field of plant extraction and daily chemical industry, and specifically relates to the application of highland barley fermentation liquid. Background technique [0002] We all know that our skin is our largest organ and protects us from the harsh environment of the outside world. However, with the increase of age and the influence of other factors, changes in the expression of related proteins in our skin structure can cause changes in the external phenotype of the skin, such as increased wrinkles and decreased elasticity. Protein expression in the skin is regulated by genes. [0003] COL4A1 (collagen type IV alpha 1chain) gene encodes type IV collagen, which is the main component of basement membrane. In the basement membrane, collagen type IV, laminin 5, heparin and many other molecules form a stable and orderly grid structure, which plays an important role in the construction and stability of the basement membrane. Up...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61Q19/08A61Q19/00
CPCA61K8/9794A61Q19/08A61Q19/00A61K2800/85
Inventor 李俊蒋丹丹孙方卉章漳黄俊
Owner JALA GROUP CORPORATION
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